Skip to main content
Figure 4 | BMC Medical Genomics

Figure 4

From: Cross-laboratory validation of the OncoScan® FFPE Assay, a multiplex tool for whole genome tumour profiling

Figure 4

Marker view of Mutation Score for A) BRAF:p.V600E:c.1799T > A and B) KRAS:p.G12D/V:c.35G > A/T. Each point represents a sample, with red points representing a high confidence calls, blue points representing a low confidence call and grey point representing an undetected call. The vertical purple lines mark the lower confidence threshold and the high confidence threshold for mutation calls. Each box plot indicates the distribution of Mutation Score for hundreds of normal samples in the universal reference believed to be absent for that SM. A) Shows the Mutation Scores for 73 samples pre-validated for BRAF:p.V600E:c.1799T > A. The overall OncoScan® assay high confidence call concordance for BRAF:p.V600E:c.1799T > A to the pre-validated SM calls is 100%. B) shows the Mutation Scores for 85 samples pre-validated for KRAS:p.G12D/V:c.35G > A/T. The overall OncoScan® assay high confidence call concordance for KRAS:p.G12D/V:c.35G > A/T to the pre-validated SM calls is 89%.

Back to article page