Representative H&E images and different marker expressions. (a) Low-grade non-invasive neoplasia (group A) complete intestinal type (I-type). Tumour glands are rarely and frequently positive for MUC2 and CD10, respectively, and negative for MUC5AC and MUC6. In contrast, residual normal glands are positive; (b) High-grade non-invasive neoplasia (group B), complete gastric type (G-type). Tumour glands are positive for MUC5AC and MUC6, and negative for MUC2 and CD10; (c) invasive intramucosal tubular adenocarcinoma (group C), gastrointestinal type (GI-type). Tumour glands are positive for MUC5AC, MUC6, and MUC2, and negative for CD10.