MiRNA targeted the signaling pathways of upregulated genes in coronary atherosclerotic lesion. The data which compared coronary atherosclerotic plaque and IMA (internal mammary artery) were obtained from GEO database. SAM was used to analyze the significantly differentially expressed genes (FDR<0.05). Those genes enriched pathways and miRNA target gene pathways were clustered by DAVID based on Reactome pathway. A: Whole blood miRNAs target pathways. B: plasma miRNAs target pathways. Illustration combined the miRNA target pathways which were also involved in the coronary atherosclerosis plaque.