MiRNA targeted the signaling pathways of upregulated genes from macrophages in ruptured atherosclerotic plaque. The data which compared macrophage in ruptured atherosclerotic plaque with in stable plaque were obtained from GEO database. SAM was used to analyze the significantly differentially expressed genes (FDR<0.05). Those genes enriched pathways and miRNA target gene pathways were clustered by DAVID based on Reactome pathway. A: Whole blood miRNAs target pathways. B: plasma miRNAs target pathways. Illustration combined the miRNA target pathways which were also involved in the coronary atherosclerosis plaque.