Figure 3

miR-10b is associated with age of onset and striatal involvement. In 26 Vonsattel grade 2, 3 and 4 HD brains, both mature miR-10b sequences (−5p and −3p) have FDR-significant relationships to CAG-adjusted Hadzi-Vonsattel striatal score (A and B) and CAG-adjusted onset age (C and D). Y-axes show the variance stabilizing transformation expression values after batch correction and shows that miR-10b-5p is expressed at much higher levels than miR-10b-3p. Grade 0 cases are not included, as they have neither onset age nor H-V striatal score.