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Table 1 Synopsis of selected relevant biological processes enriched for genes mapping to grade-CpGs (p < 0.05)

From: The DNA methylation drift of the atherosclerotic aorta increases with lesion progression

Category Genes
Fc-gamma receptor phagocytosis DNM3, LYN, PIK3CD, WASF2, PIP5K1B, PIP5K1A, PRKCE, AMPH, MYO10, RAC1, SCIN, PPAP2A, DNM1
Type 2 diabetes mellitus PRKCZ, IRS2, PIK3CD, CACNA1E, MAPK10, MAFA, CACNA1C, PRKCE, CACNA1A, CACNA1B
T-cell receptor signaling HLA-DRB1, PRKAR1B, CREBBP, GNAS, CSK
Gene regulation by PPAR-alpha LPL, PDGFA, PRKAR1B, EHHADH, CREBBP, HSPA1A, NCOR2
Interaction with ZEB1 949 genes*
Interaction with PPAR-gamma 924 genes*
Tissue specificity:  
Leukocyte CAST, KLF6, TRAF2, TNXB, HLA-DRB1, NTF3, MYO7A, RHD, HLA-C, TLR5, MEN1, JUP, CD9, IKBKE, UMPS, ADAP2, NT5E
Lymphocyte HLA-DRB1, HLA-C, HLA-DPB1
  1. *List available upon request. PPAR, Peroxisome proliferator-activated receptor; ZEB1, Zinc finger E-box binding homeobox 1.