Expansion of analysis to 7 datasets yields 120 robust signatures. (A) Overlap analysis of gene sets significantly correlated with survival across seven datasets (p < 0.05) reveals 120 “robust” gene sets. (B) A gene signature containing genes that are differentially expressed between pediatric tumors and normal tissue. (C) A gene signature whose genes are associated with periodic cell cycle expression. (D) A gene signature whose genes are associated with histologic grade. (E) A gene signature containing genes stimulated by EGF in HeLa cells. (B-E) are examples of the 120 robust gene sets. In (B) and (C), high signature activity has a protective effect (hr < 1), while in (D) and (E) high signature activity has a deleterious effect (hr > 1).