Figure 6

A gene set network reveals a module highly enriched in cell proliferation genes. Gene sets significantly associated with survival (FDR < 0.01) in the van de Vijver dataset were selected and dichotomized based on having a negative effect hazard ratio (hr ≥ 1.00) or a positive effect hazard ratio (hr < 1.00). A network was then created from the two groups of genes linking the gene sets (nodes) by the number of genes they had in common (edges). This analysis revealed a module (solid box) made up of the robust gene sets whose genes were enriched in cell proliferative-based functions.