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Table 4 Sensitivity of bronchoscopy, the classifier, and the combined procedures for patients with lung cancer in the test set

From: Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy

Histology Sub-type N Bronchoscopy sensitivity Classifier sensitivity Combined sensitivity
All cancers   78 51%a 92%b 96%c
SCLC   14 64% 100% 100%
NSCLC   64 48% 91% 95%
  Adenocarcinoma 18 33% 83% 89%
  Squamous 27 56% 92% 96%
  Large cell 4 25% 100% 100%
  Undefined 15 60% 83% 93%
Histology Stage     
SCLC      
  Limited 9 78% 100% 100%
  Extensive 5 40% 100% 100%
NSCLC      
  1 14 36% 100% 100%
  2 2 50% 100% 100%
  3 25 52% 92% 96%
  4 22 55% 80% 91%
  Unknown 1 0% 100% 100%
  1. Of 163 patients who underwent a diagnostic bronchoscopy procedure for suspicion of lung cancer, 78 were diagnosed with cancer. A lung cancer diagnosis was made at bronchoscopy (a) in 40 patients (51%; 95% CI, 40-62%), and in the remaining lung cancer patients where no diagnosis was made at bronchoscopy, (b) the classifier correctly predicted 34 of them (89%; 95% CI, 75-96%). The classifier combined with bronchoscopy (c) yielded a detection of 74 of 78 (95%; 95% CI, 87-98%) patients with lung cancer. The sensitivities of bronchoscopy, the classifier, and the combined procedures are also shown for lung cancers according to sub-type and stage.