Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy

Table 4 Sensitivity of bronchoscopy, the classifier, and the combined procedures for patients with lung cancer in the test set

Histology	Sub-type	N	Bronchoscopy sensitivity	Classifier sensitivity	Combined sensitivity
All cancers		78	51%^a	92%^b	96%^c
SCLC		14	64%	100%	100%
NSCLC		64	48%	91%	95%
	Adenocarcinoma	18	33%	83%	89%
	Squamous	27	56%	92%	96%
	Large cell	4	25%	100%	100%
	Undefined	15	60%	83%	93%
Histology	Stage
SCLC
	Limited	9	78%	100%	100%
	Extensive	5	40%	100%	100%
NSCLC
	1	14	36%	100%	100%
	2	2	50%	100%	100%
	3	25	52%	92%	96%
	4	22	55%	80%	91%
	Unknown	1	0%	100%	100%

Of 163 patients who underwent a diagnostic bronchoscopy procedure for suspicion of lung cancer, 78 were diagnosed with cancer. A lung cancer diagnosis was made at bronchoscopy (a) in 40 patients (51%; 95% CI, 40-62%), and in the remaining lung cancer patients where no diagnosis was made at bronchoscopy, (b) the classifier correctly predicted 34 of them (89%; 95% CI, 75-96%). The classifier combined with bronchoscopy (c) yielded a detection of 74 of 78 (95%; 95% CI, 87-98%) patients with lung cancer. The sensitivities of bronchoscopy, the classifier, and the combined procedures are also shown for lung cancers according to sub-type and stage.

ISSN: 1755-8794