Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity

Table 1 Characteristics of the groups of patients for which genome-wide expression profiling was performed

	T2DM	MetS	Healthy controls	p-value	p-value	p-value
	n = 6	n = 4	n = 3	T2DM vs C	MetS vs C	MetS vs T2DM
Age (years)	59.2	60.9	22.7	<0.0001	0.001	0.76
Sex (m/f)	6/0	3/1	3/0	1	1	0.40
Height (cm)	172.2	174.9	187.3	0.001	0.09	0.59
Weight (kg)	84.2	83.4	74.2	0.14	0.36	0.91
BMI (kg/m2)	28.5	27.1	21.1	0.02	0.03	0.56
Waist (cm)	102.1	97.6	79.2	0.02	0.07	0.57
Syst. BP (mm Hg)	143.5	133.7	114.7	0.02	0.06	0.32
Diast. BP (mm Hg)	85.3	84.2	70	0.03	0.06	0.87
FPG (mmol/l)	8.4	6.7	4.6	0.0002	0.0008	0.005
HbA1c (%)	6.6	5.9	na	na	na	0.10
Tot Chol (mmol/l)	4.8	5.2	4.4	0.51	0.24	0.48
HDL (mmol/l)	1.1	1.7	1.6	0.006	0.52	0.002
LDL (mmol/l)	3	3	2.4	0.34	0.25	0.97
TG (mmol/l)	1.9	1	0.9	0.02	0.66	0.01

BMI; body mass index, Syst BP; systolic blood pressure, Diast BP; diastolic BP, FPG; fasting plasma glucose, HbA1c; hemoglobin A1c, Tot Chol; Total cholesterol, HDL; high density lipoproteins, LDL; low density lipoproteins, TG; triglycerides, na; not available, p-values were calculated by Student’s T-test, or Fisher’s exact for sex. p values <0.05 were considered significant (highlighted in bold)

ISSN: 1755-8794