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Table 2 Gene ontology analysis of genes expressed at higher and lower levels in T2DM vs MetS

From: Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity

GO analysis of genes expressed at higher levels in T2DM vs MetS:
Biological process nr in genome nr sign genes p-value
Metabolic process 8,127 183 5.13E-04
Primary metabolic process 7,813 175 1.06E-03
Protein transport 1,542 44 3.29E-03
Intracellular protein transport 1,542 44 3.29E-03
Cell cycle 1,602 45 3.94E-03
GO analysis of genes expressed at lower levels in T2DM vs MetS:
Metabolic process 8,127 113 1.15E-06
Primary metabolic process 7,813 109 2.04E-06
Translation 453 14 1.75E-04
Organelle organization 295 11 1.83E-04
Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3,782 58 2.04E-04
Establishment or maintenance of chromatin architecture 269 10 3.68E-04
Protein metabolic process 3,178 49 6.75E-04
Transcription from RNA polymerase II promoter 2,214 37 8.63E-04
RNA metabolic process 663 16 9.19E-04
Transcription 2,224 37 9.36E-04
Cell cycle 1,602 29 1.02E-03
Nuclear mRNA splicing, via spliceosome 371 11 1.21E-03
Cellular component organization 1,255 24 1.39E-03
mRNA processing 456 12 1.98E-03
Hemopoiesis 183 6 9.83E-03