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Table 3 Gene set enrichment analysis

From: Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity

A. Significant gene sets expressed at higher levels in T2DM vs MetS subjects
Name Size NES NOM p-val FDR q-val
DEBIASI_REOVIRUS_HEK293_UP 227 −2.08 0.000 0.024
JI_IFNA_INDUCED_PBMC_EX_VIVO 325 −2.05 0.000 0.024
ROTH_HTERT_UP 14 −2.03 0.000 0.020
FLECHNER_KIDNEY_TRANSPLANT_WELL_UP 496 −1.98 0.000 0.034
UVB_SCC_UP 83 −1.96 0.000 0.042
MMS_HUMAN_LYMPH_LOW_4HRS_DN 16 −1.94 0.000 0.046
GRANDVAUX_IRF3_UP 13 −1.94 0.000 0.041
CHEN_HOXA5_TARGETS_UP 195 −1.92 0.000 0.045
DORSAM_HOXA9_DN 30 −1.92 0.000 0.042
DORSAM_HOXA9_UP 32 −1.89 0.002 0.062
HDACI_COLON_SUL12HRS_DN 26 −1.88 0.000 0.059
WANG_ROTAVIRUS_INFECTION_PBMC_UP 48 −1.88 0.000 0.056
MMS_MOUSE_LYMPH_HIGH_4HRS_UP 35 −1.87 0.000 0.062
TAKEDA_NUP8_HOXA9_3D_DN 28 −1.86 0.002 0.069
ZUCCHI_EPITHELIAL_UP 42 −1.84 0.000 0.082
B. Significant gene sets expressed at lower levels in T2DM vs MetS subjects
Name Size NES NOM p-val FDR q-val
POUWKRAAN_CYTOTOXIC_CELLS 57 2.29 0 0.000
DEBIASI_REOVIRUS_HEK293_DN 214 2.10 0 0.003
BASSO_REGULATORY_HUBS 129 2.09 0 0.002
LIN_WNT_UP 51 2.08 0 0.002
ROSS_MLL_FUSION 73 2.05 0 0.002
BRCA1_OVEREXP_DN 102 2.01 0 0.005
PALMER_CD8_CELLS 16 2.01 0 0.004
YU_CMYC_DN 44 2.01 0 0.004
FALT_BCLL_UP 43 2.00 0 0.004
WANG_ROTAVIRUS_INFECTION_PBMC_DN 133 1.97 0 0.007
FERRANDO_MLL_T_ALL_UP 86 1.97 0 0.006
DNA_REPLICATION_REACTOME 44 1.88 0 0.025
ET743_HELA_DN 17 1.87 0 0.027
NING_COPD_UP 141 1.86 0 0.030
NAKAJIMA_MCSMBP_MAST 47 1.86 0 0.029
  1. The top 15 significant pathways are listed, ranked on Normalized Enrichment Score (NES)