Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity

Table 3 Gene set enrichment analysis

A. Significant gene sets expressed at higher levels in T2DM vs MetS subjects
Name	Size	NES	NOM p-val	FDR q-val
DEBIASI_REOVIRUS_HEK293_UP	227	−2.08	0.000	0.024
JI_IFNA_INDUCED_PBMC_EX_VIVO	325	−2.05	0.000	0.024
ROTH_HTERT_UP	14	−2.03	0.000	0.020
FLECHNER_KIDNEY_TRANSPLANT_WELL_UP	496	−1.98	0.000	0.034
UVB_SCC_UP	83	−1.96	0.000	0.042
MMS_HUMAN_LYMPH_LOW_4HRS_DN	16	−1.94	0.000	0.046
GRANDVAUX_IRF3_UP	13	−1.94	0.000	0.041
CHEN_HOXA5_TARGETS_UP	195	−1.92	0.000	0.045
DORSAM_HOXA9_DN	30	−1.92	0.000	0.042
DORSAM_HOXA9_UP	32	−1.89	0.002	0.062
HDACI_COLON_SUL12HRS_DN	26	−1.88	0.000	0.059
WANG_ROTAVIRUS_INFECTION_PBMC_UP	48	−1.88	0.000	0.056
MMS_MOUSE_LYMPH_HIGH_4HRS_UP	35	−1.87	0.000	0.062
TAKEDA_NUP8_HOXA9_3D_DN	28	−1.86	0.002	0.069
ZUCCHI_EPITHELIAL_UP	42	−1.84	0.000	0.082
B. Significant gene sets expressed at lower levels in T2DM vs MetS subjects
Name	Size	NES	NOM p-val	FDR q-val
POUWKRAAN_CYTOTOXIC_CELLS	57	2.29	0	0.000
DEBIASI_REOVIRUS_HEK293_DN	214	2.10	0	0.003
BASSO_REGULATORY_HUBS	129	2.09	0	0.002
LIN_WNT_UP	51	2.08	0	0.002
ROSS_MLL_FUSION	73	2.05	0	0.002
BRCA1_OVEREXP_DN	102	2.01	0	0.005
PALMER_CD8_CELLS	16	2.01	0	0.004
YU_CMYC_DN	44	2.01	0	0.004
FALT_BCLL_UP	43	2.00	0	0.004
WANG_ROTAVIRUS_INFECTION_PBMC_DN	133	1.97	0	0.007
FERRANDO_MLL_T_ALL_UP	86	1.97	0	0.006
DNA_REPLICATION_REACTOME	44	1.88	0	0.025
ET743_HELA_DN	17	1.87	0	0.027
NING_COPD_UP	141	1.86	0	0.030
NAKAJIMA_MCSMBP_MAST	47	1.86	0	0.029

The top 15 significant pathways are listed, ranked on Normalized Enrichment Score (NES)

ISSN: 1755-8794