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Table 4 Gene ontology (GO) analysis of genes related to reovirus infection [26]

From: Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity

GO analysis of genes expressed at higher levels in reovirus-infected cells: Upreg. in RI Upreg in RI, and T2DM
Biological Process nr in genome nr sign genes p-value nr sign genes p-value
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3782 75 7.78E-09 22 5.74E-03
primary metabolic process 7813 120 9.01E-08 40 7.65E-04
metabolic process 8127 120 1.03E-06 40 1.87E-03
response to interferon-gamma 113 9 3.90E-06 5 4.46E-05
intracellular signaling cascade 1492 34 1.68E-05 11 1.16E-02
monosaccharide metabolic process 202 10 6.56E-05 6 6.80E-05
protein amino acid phosphorylation 654 19 7.17E-05 12 1.97E-06
response to stress 496 16 8.33E-05 6 6.86E-03
MAPKKK cascade 454 15 1.07E-04 5 1.93E-02
cell cycle 1602 31 7.28E-04 9 9.23E-02
protein modification process 1330 23 1.32E-02 13 4.87E-04
GO analysis of genes expressed at lower levels in reovirus-infected cells: Downreg. in RI Downreg in RI, and T2DM
Biological Process nr in genome nr sign genes p-value nr sign genes p-value
primary metabolic process 7813 110 3.70E-06 41 2.28E-03
metabolic process 8127 113 4.35E-06 41 5.27E-03
cell adhesion 1301 29 4.56E-05 11 7.40E-03
protein modification process 1330 29 6.72E-05 11 8.66E-03
protein amino acid phosphorylation 654 18 1.17E-04 7 9.91E-03
  1. GO analysis was performed on genes which were expressed at higher or lower levels after reovirus infection (RI), and of reovirus-regulated genes that were either up- or down regulated in T2DM vs MetS individuals, identified by gene set enrichment analysis. P-values < 10E-4 are included if reached for one of the analyses