Table 4 Gene ontology (GO) analysis of genes related to reovirus infection [26]
GO analysis of genes expressed at higher levels in reovirus-infected cells: | Upreg. in RI | Upreg in RI, and T2DM | |||
|---|---|---|---|---|---|
Biological Process | nr in genome | nr sign genes | p-value | nr sign genes | p-value |
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 3782 | 75 | 7.78E-09 | 22 | 5.74E-03 |
primary metabolic process | 7813 | 120 | 9.01E-08 | 40 | 7.65E-04 |
metabolic process | 8127 | 120 | 1.03E-06 | 40 | 1.87E-03 |
response to interferon-gamma | 113 | 9 | 3.90E-06 | 5 | 4.46E-05 |
intracellular signaling cascade | 1492 | 34 | 1.68E-05 | 11 | 1.16E-02 |
monosaccharide metabolic process | 202 | 10 | 6.56E-05 | 6 | 6.80E-05 |
protein amino acid phosphorylation | 654 | 19 | 7.17E-05 | 12 | 1.97E-06 |
response to stress | 496 | 16 | 8.33E-05 | 6 | 6.86E-03 |
MAPKKK cascade | 454 | 15 | 1.07E-04 | 5 | 1.93E-02 |
cell cycle | 1602 | 31 | 7.28E-04 | 9 | 9.23E-02 |
protein modification process | 1330 | 23 | 1.32E-02 | 13 | 4.87E-04 |
GO analysis of genes expressed at lower levels in reovirus-infected cells: | Downreg. in RI | Downreg in RI, and T2DM | |||
Biological Process | nr in genome | nr sign genes | p-value | nr sign genes | p-value |
primary metabolic process | 7813 | 110 | 3.70E-06 | 41 | 2.28E-03 |
metabolic process | 8127 | 113 | 4.35E-06 | 41 | 5.27E-03 |
cell adhesion | 1301 | 29 | 4.56E-05 | 11 | 7.40E-03 |
protein modification process | 1330 | 29 | 6.72E-05 | 11 | 8.66E-03 |
protein amino acid phosphorylation | 654 | 18 | 1.17E-04 | 7 | 9.91E-03 |