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Table 5 Transcription factor binding site analysis of differentially expressed genes in T2DM versus MetS patients

From: Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity

A. Analysis of genes that were expressed at significantly higher levels in T2DM versus MetS patients
Name Number of hits in the submitted regions Total number of hits on genome p-value
HIF1 148 4,853 1.25E-12
MYC 214 9,078 1.08E-07
STRA13 25 466 3.06E-07
ARNT 46 1,326 2.33E-06
XBP1 67 2,323 8.31E-06
SREBP1 74 2,807 5.46E-05
ATF4 176 8,147 1.33E-04
HES1 183 8,691 3.37E-04
E2F1DP1 302 15,241 3.47E-04
DEC 79 3,322 6.99E-04
B. Analysis of genes that were expressed at significantly lower levels in T2DM versus MetS patients
Name Number of hits in the submitted regions Total number of hits on genome p-value
GABP 50 2,358 2.64E-08
PEA3 112 7,400 5.40E-08
CETS168 79 4,918 4.95E-07
AR 71 4,314 7.78E-07
HIF1 73 4,853 1.17E-05
DEC 54 3,322 2.04E-05
E2F1DP1 180 15,241 6.43E-05
TFE 58 3,881 1.00E-04
MYC 113 9,078 2.10E-04
NRF1 19 919 6.45E-04
E2F1DP2 140 12,122 8.78E-04
  1. Significant binding sites are shown with a p-value <0.001