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Table 6 Genes with altered expression after in vivo exposure to high blood glucose

From: Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity

Downregulated genes after hyperglycemia       
Gene name Symbol Controls (n = 3) MetS (n = 4) T2DM (n = 6)
   FC q-value FC q-value FC q-value
Granzyme B GZMB 0.42 0.00 0.71 0.00 0.97 98.95
Granulysin GNLY 0.47 0.00 0.92 88.23 1.07 96.96
Perforin 1 PRF1 0.48 0.00 0.77 75.30 0.96 98.64
Fibroblast growth factor binding protein 2 FGFBP2 0.50 0.00 1.00 99.70 1.17 96.96
Chloride intracellular channel 3 CLIC3 0.56 0.00 0.95 93.51 1.03 98.21
Killer cell immunoglobulinlike receptor, two domains, long cytoplasmic tail, 4 KIR2DL4 0.62 0.00 0.89 65.06 1.05 96.96
Chromosome 1 open reading frame 162 C1orf162 0.66 0.00 0.75 0.00 0.90 81.90
Cystatin F (leukocystatin) CST7 0.67 0.00 1.01 97.65 1.03 98.21
Galectin 1 LGALS1 0.68 0.00 0.97 98.10 0.97 98.72
FK506 binding protein 5 FKBP5 0.68 9.78 0.51 0.00 0.71 37.55
TSC22 domain family, member 3 TSC22D3 0.73 10.48 0.70 0.00 0.64 0.00
Dual specificity phosphatase 1 DUSP1 1.02 96.30 0.71 70.35 0.69 0.00
Myeloid cell leukemia sequence 1 (BCL2related) MCL1 1.00 97.20 0.89 67.05 0.81 0.00
Upregulated genes after hyperglycemia       
Interleukin 8 IL8 1.24 66.30 1.44 0.00 1.46 22.49
HIV1 Tat specific factor 1 pseudogene LOC401233 1.18 67.90 1.24 0.00 1.07 96.96
  1. FC indicates fold change compare to baseline levels. q-value indicates the false discovery rate (%). Significant changes are indicated in bold (q < 5 %). Gene symbols indicated in bold are cytotoxicity related, and visualized in Fig. 4