Skip to main content
Fig. 1 | BMC Medical Genomics

Fig. 1

From: Co-expression network of neural-differentiation genes shows specific pattern in schizophrenia

Fig. 1

Module preservation analysis. a Dendrograms produced by average hierarchical clustering using topological overlapping matrix dissimilarity. Colours represent different modules. Upper panel shows modules in control subjects (CTS; blue, brown, yellow and turquoise) compared to patients with schizophrenia (SZP). Lower panel shows modules in patients with schizophrenia (blue, brown and turquoise) compared to modules in control subjects. bLeft panel shows the median preservation rank (y-axis) in relation to module size (x-axis). Each circle represents a module labelled in different colours (blue, turquoise, yellow and brown). Right panel shows the Zsummary (y-axis) in function of module size. Dashed lines represent thresholds 2 and 10: ≥10: high preservation; 2 < Zsummary <10: moderate preservation; <2: low preservation. The panels show that the blue module is more preserved in control and patients whilst the turquoise module is less preserved. c Connectivity patterns (correlation network adjacencies) between genes from the turquoise module in controls (control) and patients (schizophrenia) showing a large loss of connectivity among genes in patient’s module compared to control modules. Line thickness represents the connectivity pattern and line colour reflects the absolute correlation: −1 (negative) to 1 (positive). This module is enriched in genes related to response to negative regulation of cell differentiation and oxidative stress

Back to article page