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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems

Fig. 1

Genes downregulated in the SCC-like subtype. a Transcription factors strongly downregulated in the SCCL subtype included RXRA, PPARG, FOXA1, GATA3, GATA2, TBX2, TBX3 and ELF3. b Enrichment of RXRA, PPARG, FOXA1 and GATA3 binding in the SCCL-down genes. (red, query signature; blue, 105 randomly sampled gene lists of equal size to the query signature). c Colocalization of RXRA, PPARG, FOXA1 and GATA3 binding events in SCCL-down genes using the Kittler data set in a ±1000 bp window centered on the first factor in each subpanel. d A 42 gene QTC cluster, enriched for the GO term lipid metabolism included the transcription factors PPARG, FOXA1, GATA3, TBX3 and the adipogenesis regulatory factor ADIRF. e Downregulated genes involved in lipid metabolism (n = 233) in the TCGA BC basal-like subtype

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