Fig. 1
From: Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems
Genes downregulated in the SCC-like subtype. a Transcription factors strongly downregulated in the SCCL subtype included RXRA, PPARG, FOXA1, GATA3, GATA2, TBX2, TBX3 and ELF3. b Enrichment of RXRA, PPARG, FOXA1 and GATA3 binding in the SCCL-down genes. (red, query signature; blue, 105 randomly sampled gene lists of equal size to the query signature). c Colocalization of RXRA, PPARG, FOXA1 and GATA3 binding events in SCCL-down genes using the Kittler data set in a ±1000 bp window centered on the first factor in each subpanel. d A 42 gene QTC cluster, enriched for the GO term lipid metabolism included the transcription factors PPARG, FOXA1, GATA3, TBX3 and the adipogenesis regulatory factor ADIRF. e Downregulated genes involved in lipid metabolism (n = 233) in the TCGA BC basal-like subtype