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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems

Fig. 4

FOXM1 regulated genes in UC. a A QTC cluster of 129 genes linked to the late cell cycle including the transcription factors FOXM1, among others. PLK1 mRNA expression levels are indicated. b Enrichment of FOXM1 promoter binding in late cell cycle QTC genes (red, query signature; blue, 105 randomly sampled gene lists of equal size to the query signature). c Transcription factors associated with cell cycle regulation and the DREAM complex colocalizes with FOXM1 binding events in the late cell cycle QTC gene promoters. d Heat map indicating the percentage of FOXM1 and PLK1 positive tumor nuclei in TMA cores. e FOXM1 (top) and PLK1 (bottom) stained sections of representative tumors across the UC subtypes. f The UC derived late cell cycle gene cluster in the breast cancer TCGA gene expression dataset

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