Fig. 5
From: Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems
UroB, GU and SCC-like tumors lose transcription factors involved in urothelial differentiation and have altered expression of intracellular lipid-binding proteins. a Heat map illustrating nuclear IHC staining for transcription factors involved in urothelial differentiation. IHC scores for the individual transcription factors (top). Loss of any transcription factor (IHC score <0.5) indicated with blue (bottom). b FABP4, FABP5 and CRABP2 mRNA expression across UC subtypes. Red bars up, expression above median; green bars down expression below median c The ratio between FABP4/5 and CRABP2 mRNA levels, respectively