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Fig. 7 | BMC Medical Genomics

Fig. 7

From: Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems

Fig. 7

Cell divisions show preferential localization near the basal lamina and to close to 90 ° in low grade Urobasal tumors. a Immunohistochemical stainings of five Urobasal A cases (1–5) and two GU/SCCL cases (6–7) with anti-CCNB1. b Immunohistochemical stainings of five Urobasal A cases (1–5) and two GU/SCCL cases (6–7) with anti-PLK1. c Immuno-histochemical stainings of five Urobasal A cases (1–5) and two GU/SCCL cases (6–7) with antibodies for histone H3 phosphorylated at Ser10. d Bee-swarm dot-plots showing the distribution of division angles relative cell layer in low-grade vs. high-grade tumors and in Urobasal vs. GU/SCCL tumors. Red lines indicate median angle for each group. e Median observed basal cell division angles in low-grade vs. high-grade tumors and in Urobasal vs. SCCL tumors (red lines) plotted against the distribution of medians from 104 randomly generated sets of angles of equal size

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