Fig. 2

Gene signatures reflect the clinical prognostic status of different subtypes of embryonal brain tumors. (a) Overall survival rates of the INI1(−) AT/RTs (n = 19) and INI1(+) AT/RT-like (n = 16) cases included in the IHC analysis. (b) Survival curves of 199 cases of primary pediatric CNS embryonal tumors (162 MBs, 19 AT/RTs, and 16 INI1(+) AT/RT-like cases) that were included in the IHC validation study. All patients with AT/RTs or AT/RT-like tumors had a worse overall survival than patients with MBs (P < 0.0001). (c) An MDS plot based on genes that are differentially expressed in the 3 subtypes of embryonal brain tumors (q < 0.001) show the relationships among AT/RTs, MBs, INI1(+) AT/RT-like tumors and different stem or progenitor cells. ESC: embryonic stem cell; NSC: adult neural stem cell; FB: fetal brain tissues. (d) Analysis of the transcriptome distance between AT/RTs, MBs, INI1(+) AT/RT-like tumors and different stem or progenitor cells. AT/RT-L: AT/RT-like