Integrated genomics has identified a new AT/RT-like yet INI1-positive brain tumor subtype among primary pediatric embryonal tumors

Table 1 Clinical details and INI1 IHC data of PEBT cases enrolled in aCGH and transcriptome studies

Case	Age	Sex	Site	Histo.	INI1	SMARCA4	aCGH	mRNA	microRNA
No.	(yr)	Sex	Site	Dx	IHC	IHC	aCGH	array	array
L01	8.3	m	cblm	AT/RT-like	+	+	+	+	+
L02	4.2	m	cblm	AT/RT-like	+	+	+	ND	ND
L06	3.5	f	cblm	AT/RT-like	+	+	+	ND	ND
L07	9.8	m	cblm	AT/RT-like	+	+	+	ND	ND
L08	9.4	f	cblm	AT/RT-like	+	+	+	+	+
A03	2.3	f	cblm	AT/RT	-	+	+	ND	ND
A04	4.5	f	lat. vent.	AT/RT	-	+	+	+	+
A05	0.1	m	cblm	AT/RT	-	+	+	ND	ND
A09	5.2	f	cblm	AT/RT	-	+	+	+	+
A10	1.6	m	cblm	AT/RT	-	+	ND	+	+
A11	1.4	f	cblm	AT/RT	-	+	ND	+	ND
A12	0.6	f	cblm	AT/RT	-	+	ND	+	ND
A13	5	m	cblm	AT/RT	-	+	ND	+	ND
A14	1.6	m	cblm	AT/RT	-	+	ND	+	ND
M01	8.7	m	cblm	MB, cl	+	+	+	ND	ND
M02	9.2	f	cblm	MB, an	+	+	+	ND	ND
M03	4	m	cblm	MB, cl	+	+	+	ND	ND
M04	6.3	m	cblm	MB, ds	+	+	+	ND	ND
M05	3.5	f	cblm	MB, ds	+	+	+	ND	ND
M06	9.4	m	cblm	MB, cl	+	+	+	ND	ND
M07	7.6	m	cblm	MB, an	+	+	+	ND	ND
M08	14.3	f	cblm	MB, cl	+	+	+	ND	ND
M09	13.6	m	cblm	MB, cl	+	+	+	+	ND
M10	12.2	f	cblm	MB, cl	+	+	+	ND	ND
M11	4.1	f	cblm	MB, cl	+	+	+	+	ND
M12	4.3	m	cblm	MB, cl	+	+	ND	+	ND
M13	3.2	m	cblm	MB, cl	+	+	ND	+	+
M14	3	m	cblm	MB, cl	+	+	ND	+	+
M15	1.5	f	cblm	MB, an	+	+	ND	+	+
M16	9.1	f	cblm	MB, an	+	+	ND	+	+
M17	13	f	cblm	MB (*)	+	+	ND	+	+
M18	18.2	m	cblm	MB, cl	+	+	ND	+	+
M19	5.8	f	cblm	MB, cl	+	+	ND	+	+
M20	5.1	m	cblm	MB, cl	+	+	ND	+	+
M21	3	m	cblm	MB, cl	+	+	ND	+	+
M22	8.5	f	cblm	MB, an	+	+	ND	+	+
M23	2.2	m	cblm	MB, ds	+	+	ND	+	+
M24	5.8	f	cblm	MB (*)	+	+	ND	+	ND
M25	7.6	f	cblm	MB, cl	+	+	ND	+	+
M26	12.2	m	cblm	MB, an	+	+	ND	+	ND
M27	6.5	f	cblm	MB, an	+	+	ND	+	ND
M28	2.1	m	cblm	MB, ds	+	+	ND	+	ND
M29	6.3	m	cblm	MB, cl	+	+	ND	+	ND
M30	10	m	cblm	MB, an	+	+	ND	+	ND

Site: cblm: cerebellum, lat.vent: lateral ventricle
Histo. Dx. (Histopathological diagnosis): cl: classic, ds: demoplastic, an: anaplastic
INI1 IHC: −: loss of INI1 expression (INI1-), +: retained INI1 expression (INI1+);
SMARCA4 IHC: −: loss of SMARCA4 expression, +: retained SMARCA4 expression;
aCGH & GEM: +:performed, ND: not determined
(*)M17 with focal anaplasia; M24 with myogenic and melanocytic differentiation

ISSN: 1755-8794