Fig. 6
Significantly enriched pathways among the hub genes. A two-way evidence plot of signaling-pathway impact analysis (SPIA) for each pathway is represented by one dot. Pathways on the right of the red oblique line (red dots) are statistically significant at the 1 % threshold after Bonferroni correction of global p-values (PG) obtained by combining (by Fisher’s method) over-representation of differentially expressed genes (DEGs) in a given pathway (PPERT) and an abnormal perturbation of the pathway (PNDE). The pathways on the right of the blue oblique line (blue dots) are statistically significant after false discovery rate (FDR) correction of PG