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Table 3 Summary of LOH – what is it good for?

From: Loss of heterozygosity: what is it good for?

Hypothesis Mechanism Plausibility Frequency Impact LOH type
Classic two-hit hypothesis High frequency biallelic genetic inactivation of TSG via mutation and LOH or homozygous deletion Strong Rare High More CNN-LOH
Modified two-hit hypothesis Reduction to homozygosity of predisposition alleles Low Rare Low Unknown
Epigenetic two-hit hypothesis Biallelic inactivation through methylation and LOH Moderate Unknown Moderate More CNN-LOH
Haplo-insufficiency Single copy gene disruption through copy number loss Strong Common Moderate CNL-LOH
Multi-gene biallelic inactivation Low frequency gene disruption through all of the above mechanisms Strong Common Unknown Either