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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Harmful somatic amino acid substitutions affect key pathways in cancers

Fig. 4

Networks of proteins and pathways affected in HNC. a The selected proteins and their first neighbors in Reactome functional interaction network are highly connected. The nodes were clustered into modules (indicated by colors) using ReactomeFI plugin in cytoscape. b Statistically significantly enriched pathways (Reactome pathway database) affected in HNC. Nodes represent pathways and edges represent common proteins having roles in the connected pathways. The edge line thickness represents the number of common proteins in the two pathways. Only the selected proteins in HNC are included. c Pre-NOTCH expression and processing pathway from Reactome pathway database. This is the most frequently affected pathway in HNC samples

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