Fig. 1

Correlation between FoxM1 and PTTG1 expression in colorectal cancer. a FoxM1 closely correlates to PTTG1 expression in 7 tumor microarray datasets (upper table). Expression levels of FoxM1 and PTTG1 were obtained from a colon cancer microarray dataset (GSE2019, n = 315) and plotted in lower figure. b The top 15 genes associated with FoxM1 expression in GSE2019 dataset. Known FoxM1 target genes were bolded. PTTG1 is ranked as fifth. c Differentially expressed genes in BT-20 breast cancer cells transfected with mock or FoxM1 siRNA. The microarray data were standardized (shift genes to means of zero and scale to standard deviation of one). Two-way Hierarchical Clustering was performed. The heat map (upper figure) shows that 49 genes were differentially expressed including CEP55 and PTTG1. The lower figure indicated that the PTTG1 is statistically down-regulated by FoxM1 knock-down