Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection

Table 3 GO analysis of genes with attenuated expression in PR8-infected p53KO mice

GO ID	Category	3 dpi		6 dpi
GO ID	Category	Number of genes	Representative genes	Number of genes	Representative genes
GO:0002684	Positive regulation of immune system process	5	Ifng, Il2, Lag3, Stat6, Trat1	18	Blm, Lag3, Nfkbia, Il6, Fcer1g, Il15, Ifng, etc.
GO:0002682	Regulation of immune system process	8	Il2, Lag3, Orm1, Ifng, Trat1, Hmgb1, Jag1, Stat6	24	Blm, Orm1, Tnf, Nfkbia, Ifng, Tnfsf11, etc.
GO:0050900	Leukocyte migration	2	Ifng, Il16	6	Tnf, Ifng, Fcer1g, Il1b, Selp, Tlr2
GO:0045321	Leukocyte activation	7	Fyn, Ifng, Il2, Lag3, Stat6, Exo1, Mink1	20	Lag3, Blm, Fcgr2b, Was, Nfkbid, etc.
GO:0019882	Antigen processing and presentation	2	Ctse, Ifng	5	Ifng, Fcgr2b, Fcer1g, Slc11a1, Ctse
GO:0001776	Leukocyte homeostasis	2	Ifng, Il2	6	Ifng, Fcer1g, Gpam, Ikbkb, Il6, Pik3cd
GO:0002252	Immune effecter process	6	Ifng, Il2, Lag3, Stat6, Exo1, Irf7	17	Irf7, Tnf, Lag3, Fcgr2b, Fcer1g, Msh2, etc.
GO:0002253	Activation of immune response	1	Trat1	8	Nfkbia, Fcer1g, C1qb, Lat2, Plcg2, etc.
GO:0002200	Somatic diversification of immune receptors	4	Ifng, Il2, Stat6, Exo1	5	Ifng, Msh2, Cd40, Pms2, Exo1
GO:0002520	Immune system development	10	Hmgb1, Ifng, Il2, Jag1, Exo1, Tlx1, Six4	23	Blm, Timp1, Tnf, Tnfsf11, Cxcl13, Msh2, etc.
GO:0006955	Immune response	13	Ctla4, Cxcl1, Ifng, Mx2, Irf7, Polr3c, etc.	47	Irf7, Cxcl9, Cxcl10, Ccl2, Ccl7, etc.