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Table 5 The expression of selected genes involved in interferon signaling pathway

From: Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection

Gene symbol

Gene description

FCa (p53WT/p53KO)

3 dpi

6 dpi

Mx2

myxovirus (influenza virus) resistance 2

42.94/14.54b

37.85/2.92b

Oas2

2'-5' oligoadenylate synthetase 2

14.75/12.43

13.20/3.06b

Oas3

2'-5' oligoadenylate synthetase 3

9.39/5.46

6.37/2.41b

Eif2ak2

eukaryotic translation initiation factor 2-alpha kinase 2 (PKR)

4.98/4.71

4.53/1.60b

Gbp1

guanylate binding protein 1

2.95/1.59

2.51/1.12b

Ifitm1

interferon induced transmembrane protein 1

2.50/2.32

2.58/1.24b

Bst2

bone marrow stromal cell antigen 2 (Tetherin)

3.41/2.22

2.96/1.02b

Ifi44

interferon-induced protein 44

4.59/2.82

2.98/1.09b

Nampt

nicotinamide phosphoribosyltransferase

2.59/2.52

3.62/1.78b

Rtp4

receptor transporter protein 4

7.16/7.68

9.56/3.91b

Trex1

three prime repair exonuclease 1

6.72/11.63

8.32/2.98b

Daxx

Fas death domain-associated protein

6.27/6.39

7.79/1.59b

Ifng

interferon gamma

2.87/1.05b

6.07/0.90b

Ifnab

interferon alpha B

1.80/0.80b

2.38/0.60b

Stat4

signal transducer and activator of transcription 4

1.78/0.79

2.08/0.80b

Stat6

signal transducer and activator of transcription 6

2.28/0.81b

1.87/0.34

Irf5

interferon regulatory factor 5

2.10/3.99

2.89/1.27b

Irf7

interferon regulatory factor 7

109.99/37.81b

93.18/7.18b

  1. aFC fold change
  2. bsignificant difference in gene expression between PR8-infected p53WT and p53KO mice