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Table 5 The expression of selected genes involved in interferon signaling pathway

From: Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection

Gene symbol Gene description FCa (p53WT/p53KO)
3 dpi 6 dpi
Mx2 myxovirus (influenza virus) resistance 2 42.94/14.54b 37.85/2.92b
Oas2 2'-5' oligoadenylate synthetase 2 14.75/12.43 13.20/3.06b
Oas3 2'-5' oligoadenylate synthetase 3 9.39/5.46 6.37/2.41b
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 (PKR) 4.98/4.71 4.53/1.60b
Gbp1 guanylate binding protein 1 2.95/1.59 2.51/1.12b
Ifitm1 interferon induced transmembrane protein 1 2.50/2.32 2.58/1.24b
Bst2 bone marrow stromal cell antigen 2 (Tetherin) 3.41/2.22 2.96/1.02b
Ifi44 interferon-induced protein 44 4.59/2.82 2.98/1.09b
Nampt nicotinamide phosphoribosyltransferase 2.59/2.52 3.62/1.78b
Rtp4 receptor transporter protein 4 7.16/7.68 9.56/3.91b
Trex1 three prime repair exonuclease 1 6.72/11.63 8.32/2.98b
Daxx Fas death domain-associated protein 6.27/6.39 7.79/1.59b
Ifng interferon gamma 2.87/1.05b 6.07/0.90b
Ifnab interferon alpha B 1.80/0.80b 2.38/0.60b
Stat4 signal transducer and activator of transcription 4 1.78/0.79 2.08/0.80b
Stat6 signal transducer and activator of transcription 6 2.28/0.81b 1.87/0.34
Irf5 interferon regulatory factor 5 2.10/3.99 2.89/1.27b
Irf7 interferon regulatory factor 7 109.99/37.81b 93.18/7.18b
  1. aFC fold change
  2. bsignificant difference in gene expression between PR8-infected p53WT and p53KO mice