Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection

Table 5 The expression of selected genes involved in interferon signaling pathway

Gene symbol	Gene description	FC^a (p53WT/p53KO)
Gene symbol	Gene description	3 dpi	6 dpi
Mx2	myxovirus (influenza virus) resistance 2	42.94/14.54^b	37.85/2.92^b
Oas2	2'-5' oligoadenylate synthetase 2	14.75/12.43	13.20/3.06^b
Oas3	2'-5' oligoadenylate synthetase 3	9.39/5.46	6.37/2.41^b
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2 (PKR)	4.98/4.71	4.53/1.60^b
Gbp1	guanylate binding protein 1	2.95/1.59	2.51/1.12^b
Ifitm1	interferon induced transmembrane protein 1	2.50/2.32	2.58/1.24^b
Bst2	bone marrow stromal cell antigen 2 (Tetherin)	3.41/2.22	2.96/1.02^b
Ifi44	interferon-induced protein 44	4.59/2.82	2.98/1.09^b
Nampt	nicotinamide phosphoribosyltransferase	2.59/2.52	3.62/1.78^b
Rtp4	receptor transporter protein 4	7.16/7.68	9.56/3.91^b
Trex1	three prime repair exonuclease 1	6.72/11.63	8.32/2.98^b
Daxx	Fas death domain-associated protein	6.27/6.39	7.79/1.59^b
Ifng	interferon gamma	2.87/1.05^b	6.07/0.90^b
Ifnab	interferon alpha B	1.80/0.80^b	2.38/0.60^b
Stat4	signal transducer and activator of transcription 4	1.78/0.79	2.08/0.80^b
Stat6	signal transducer and activator of transcription 6	2.28/0.81^b	1.87/0.34
Irf5	interferon regulatory factor 5	2.10/3.99	2.89/1.27^b
Irf7	interferon regulatory factor 7	109.99/37.81^b	93.18/7.18^b

^aFC fold change
^bsignificant difference in gene expression between PR8-infected p53WT and p53KO mice