Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection

Wenjun Yan; Jianchao Wei; Xufang Deng; Zixue Shi; Zixiang Zhu; Donghua Shao; Beibei Li; Shaohui Wang; Guangzhi Tong; Zhiyong Ma

doi:10.1186/s12920-015-0127-8

Table 6 The expression of selected cytokine and chemokine genes

From: Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection

Gene symbol	Gene description	FC^a (p53WT/p53KO)
Gene symbol	Gene description	3 dpi	6 dpi
Il1b	interleukin 1 beta	2.30/3.71	2.85/0.93^b
Il6	interleukin 6	3.27/2.79	2.52/0.95^b
Il7	interleukin 7	0.65/0.47	0.34/0.83^b
Il15	interleukin 15	2.64/1.72	2.05/0.67^b
Il16	interleukin 16	4.93/0.15^b	1.20/0.99
Il3ra	interleukin 3 receptor, alpha chain	1.40/0.96	2.09/0.73^b
Il10ra	Interleukin 10 receptor, alpha (Il10ra), mRNA	3.04/3.16	4.14/1.21^b
Il17rd	interleukin 17 receptor D	0.48/0.41	0.07/0.45^b
Il17re	interleukin 17 receptor E	0.60/0.81	0.45/1.55^b
Il20rb	interleukin 20 receptor beta	0.27/0.98^b	0.73/1.33
Ccl2	chemokine (C-C motif) ligand 2 (MCP-1)	11.83/130.82^b	22.32/9.89^b
Ccl3	chemokine (C-C motif) ligand 3 (MIP-1α)	7.90/11.23	9.62/1.90^b
Ccl4	chemokine (C-C motif) ligand 4 (MIP-1β)	18.00/15.62	16.91/2.03^b
Ccl7	chemokine (C-C motif) ligand 7	42.24/79.44	52.60/8.94^b
Ccl11	chemokine (C-C motif) ligand 11	1.15/3.31	8.15/3.12^b
Ccl19	chemokine (C-C motif) ligand 19	2.55/4.33	3.68/1.83^b
Ccl25	chemokine (C-C motif) ligand 25	0.27/1.09^b	0.58/1.53
Cxcl1	chemokine (C-X-C motif) ligand 1	21.07/6.71^b	8.63/0.30^b
Cxcl9	chemokine (C-X-C motif) ligand 9	39.58/120.08^b	40.63/17.95^b
Cxcl10	chemokine (C-X-C motif) ligand 10 (IP-10)	161.21/220.07	114.77/19.91^b
Cxcl13	chemokine (C-X-C motif) ligand 13	2.48/10.71	7.60/1.71^b
Cxcl14	chemokine (C-X-C motif) ligand 14	1.38/1.93	2.10/0.96^b
Ccr6	chemokine (C-C motif) receptor 6	0.56/0.47	0.28/1.04^b
Ccrl2	chemokine (C-C motif) receptor-like 2	2.89/2.26	2.35/0.82^b
Tnf	tumor necrosis factor	9.43/34.25^b	8.90/1.06^b
Tnfrsf10b	tumor necrosis factor receptor superfamily, member 10b	0.46/2.18^b	1.26/1.80
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.27/0.08	5.88/1.81^b
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	5.86/1.08^b	0.88/0.01^b
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	2.55/2.13	3.86/1.43^b

^aFC fold change
^bsignificant difference in gene expression between PR8-infected p53WT and p53KO mice

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