RNA sequencing from human neutrophils reveals distinct transcriptional differences associated with chronic inflammatory states

Table 4 Gene ontology analysis of genes expressed in neutrophils

Category	Term	Count	P value
High expression genes
GO:0006414	Translational elongation	72	6.90E-46
GO:0006955	Immune response	169	8.73E-26
GO:0006952	Defense response	145	1.75E-20
GO:0006412	Translation	91	2.00E-17
GO:0007242	Intracellular signaling cascade	230	3.03E-17
Medium expression genes
GO:0030163	Protein catabolic process	238	2.00E-28
GO:0044265	Cellular macromolecule catabolic process	266	2.10E-28
GO:0051603	Proteolysis involved in cellular protein catabolic process	231	4.93E-28
GO:0043632	Modification-dependent macromolecule catabolic process	223	1.07E-27
GO:0019941	Modification-dependent protein catabolic process	223	1.07E-27
Low expression genes
GO:0006350	Transcription	268	6.52E-11
GO:0006974	Response to DNA damage stimulus	70	2.42E-09
GO:0006259	DNA metabolic process	85	9.66E-09
GO:0006281	DNA repair	56	2.03E-08
GO:0045449	Regulation of transcription	302	8.31E-08

Genes were classified into three groups, high-expression (25 %), medium-expression (50 %) and low expression (25 %). Gene ontology analysis was performed using DAVID. Top 20 categories for each group was presented here

ISSN: 1755-8794