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Table 4 Gene ontology analysis of genes expressed in neutrophils

From: RNA sequencing from human neutrophils reveals distinct transcriptional differences associated with chronic inflammatory states

Category Term Count P value
High expression genes
GO:0006414 Translational elongation 72 6.90E-46
GO:0006955 Immune response 169 8.73E-26
GO:0006952 Defense response 145 1.75E-20
GO:0006412 Translation 91 2.00E-17
GO:0007242 Intracellular signaling cascade 230 3.03E-17
Medium expression genes
GO:0030163 Protein catabolic process 238 2.00E-28
GO:0044265 Cellular macromolecule catabolic process 266 2.10E-28
GO:0051603 Proteolysis involved in cellular protein catabolic process 231 4.93E-28
GO:0043632 Modification-dependent macromolecule catabolic process 223 1.07E-27
GO:0019941 Modification-dependent protein catabolic process 223 1.07E-27
Low expression genes
GO:0006350 Transcription 268 6.52E-11
GO:0006974 Response to DNA damage stimulus 70 2.42E-09
GO:0006259 DNA metabolic process 85 9.66E-09
GO:0006281 DNA repair 56 2.03E-08
GO:0045449 Regulation of transcription 302 8.31E-08
  1. Genes were classified into three groups, high-expression (25 %), medium-expression (50 %) and low expression (25 %). Gene ontology analysis was performed using DAVID. Top 20 categories for each group was presented here