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Table 6 Top 10 up and down regulated differentially expressed genes in neutrophils in juvenile idiopathic arthritis with active status compared with in neutrophils in cystic fibrosis

From: RNA sequencing from human neutrophils reveals distinct transcriptional differences associated with chronic inflammatory states

Gene symbol

Base Mean_all

Base Mean_AD

Base Mean_CF

p value

Fold change

(AD vs CF)

HRK

3.254095483

6.295412043

0.212778924

0.00913228

29.58663351

ZNF724P

2.434400622

4.65602232

0.212778924

0.038928663

21.88197136

DUOX2

4.06892349

7.551846549

0.58600043

0.007728683

12.8871007

LOC145474

3.478432752

6.32498152

0.631883985

0.015249855

10.00971962

CFD

1673.012068

2996.168793

349.8553432

0.00893998

8.56402182

COL5A3

8.493207647

14.96975153

2.016663769

0.029568293

7.423027953

KIF21A

7.226812819

12.17829939

2.275326247

0.043226873

5.35233108

KLRG1

14.29693321

23.81752942

4.77633699

0.022752462

4.986568048

EFHA2

6.265641701

10.20362082

2.327662587

0.04898428

4.383633984

TRIM36

9.077531529

14.75361951

3.401443553

0.026681604

4.337458282

LOC285847

2.582363565

0.443745708

4.720981423

0.047502758

−10.63893428

PGM5

70.05844466

11.57358217

128.5433071

0.015904627

−11.10661377

LOC100133207

3.462096626

0.458530446

6.465662806

0.033308951

−14.10083641

LRRC32

2.183632721

0.229265223

4.138000219

0.042150439

−18.04896602

RPH3A

234.0009908

24.42986525

443.5721163

0.0438117

−18.15696123

FAM21B

44.9347236

4.54591393

85.32353326

3.54E-07

−18.76928041

PCOLCE2

3.287165275

0.229265223

6.345065326

0.021037444

−27.67565548

GLIS3

6.916159962

0.229265223

13.6030547

0.000110398

−59.33326704

CYP26B1

85.98114317

2.337885371

169.624401

4.17E-14

−72.55462697

TMTC1

285.5146376

6.717864103

564.3114112

0.002300462

−84.00161161