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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Development and verification of the PAM50-based Prosigna breast cancer gene signature assay

Fig. 2

Hierarchical clustering of all subtype training samples. Clustering analysis (using a Pearson’s distance metric and average linkage) was performed on the median centered normalized, Log2 transformed data. The centroid color bars below the sample dendrogram represent the significant clusters that were chosen to establish each tumor centroid. The subtype color bars represent the subtype calls using the final algorithm. Since the reduction mammoplasty normal tissue samples do not contain tumor, they were not assigned a subtype and are represented as blanks in the subtype color bars

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