Development and verification of the PAM50-based Prosigna breast cancer gene signature assay

BMC Medical Genomics

Table 1 Clinical characteristics by cohort for samples used for algorithm training

Characteristic	BC no AST	WashU	UNC	BC TAM
Median Follow Up (Years)	11.9	NA	NA	12.1
Patient Age
Mean	59.9	59.3	56.5	66.3
Stdev	13.8	15.2	15.9	9.6
Premenopausal
Yes	81	0	0	10
No	214	0	0	219
Unknown	9	118	92	3
ER Status
Positive	203	65	47	232
Negative	99	48	30	0
Unknown	2	5	15	0
Node Status
Positive	18	57	41	0
Negative	276	58	35	232
Unknown	10	3	16	0
HER2 Status
Positive	44	31	21	19
Negative	253	59	51	210
Unknown	7	28	20	3
PR Status
Positive	138	50	34	130
Negative	139	63	38	86
Unknown	27	5	20	16
Tumor Size
≤2	193	87	24	149
>2	111	29	49	83
Unknown	0	2	19	0
Grade
1	26	5	10	15
2	127	32	20	103
3	145	78	43	108
Unknown	6	3	19	6

Any missing values were not available or not collected and therefore not reportable

ISSN: 1755-8794