Fig. 4

Oncogenetic Trees. The reconstructed atom tree for stage 4S (top) shows several initial events of which only one with sublevels. Conversely, both stage 4 reconstructed atom trees (bottom) are marked branched (up to five sublevels) The root node R (yellow) is associated with a weight corresponding to the portion of mutation patterns represented by the tree. The missing portion is associated with the random mutations tree (data not shown). The edges are weighted according to the frequency of the corresponding mutation occurrence. Node color codes: the red node is associated with chromosome gain, the green node is associated with chromosome loss, and the green and red node indicates co-occurring loss and gain