Table 1 Integration-Driven Discovery (IDD) Genes in the MADAD transcriptome, with indication of compartmental allocation as defined by Esaki et al. [63]

COL6A6

collagen, type VI, alpha 6

2,08

4,22

D

CD1B

CD1b molecule

1,84

3,57

D

SPRR1B

small proline-rich protein 1B

1,68

3,20

E

CCL22

chemokine (C-C motif) ligand 22

1,65

3,13

D

MMP9

matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase)

1,51

2,84

D

IL13RA2

interleukin 13 receptor, alpha 2

1,46

2,74

D

CCL26

chemokine (C-C motif) ligand 26

1,37

2,59

D

SASH3

SAM and SH3 domain containing 3

1,35

2,56

D

IL36RN

interleukin 36 receptor antagonist

1,35

2,55

E

CCL13

chemokine (C-C motif) ligand 13

1,27

2,41

D

KIAA1644

KIAA1644

1,26

2,39

D

IL12RB1

interleukin 12 receptor, beta 1

1,23

2,34

D

XCL2

chemokine (C motif) ligand 2

1,21

2,31

D

CCL5

chemokine (C-C motif) ligand 5

1,21

2,31

D

ADAMDEC1

ADAM-like, decysin 1

1,19

2,29

D

TIFAB

TRAF-interacting protein with forkhead-associated domain, family member B

1,18

2,27

D

P2RY1

purinergic receptor P2Y, G-protein coupled, 1

1,16

2,23

E

PIK3CG

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

1,15

2,22

D

FAM124B

family with sequence similarity 124B

1,14

2,21

D

SLAMF8

SLAM family member 8

1,12

2,18

D

CXADR

coxsackie virus and adenovirus receptor

1,12

2,17

E

GPSM3

G-protein signaling modulator 3

1,11

2,16

D

HCK

hemopoietic cell kinase

1,09

2,13

D

LOC100288860

uncharacterized LOC100288860

1,09

2,12

E

MMP3

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

1,08

2,11

D

CD1E

CD1e molecule

1,07

2,10

D

KLRK1

killer cell lectin-like receptor subfamily K, member 1

1,06

2,09

D

GBP1

guanylate binding protein 1, interferon-inducible

1,06

2,09

IL23A

interleukin 23, alpha subunit p19

1,05

2,08

D

LYN

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

1,05

2,07

D

C5orf20

chromosome 5 open reading frame 20

1,05

2,06

D

CCL8

chemokine (C-C motif) ligand 8

1,04

2,06

D

RELB

v-rel avian reticuloendotheliosis viral oncogene homolog B

1,04

2,06

ACPP

acid phosphatase, prostate

1,03

2,05

E

TRAT1

T cell receptor associated transmembrane adaptor 1

1,03

2,04

D

PTX3

pentraxin 3, long

1,03

2,04

D

CD48

CD48 molecule

1,03

2,04

D

FPR3

formyl peptide receptor 3

1,02

2,03

D

TGM3

transglutaminase 3

1,02

2,03

E

CXCL11

chemokine (C-X-C motif) ligand 11

1,02

2,03

MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

1,02

2,02

D

CD6

CD6 molecule

1,02

2,02

D

SELPLG

selectin P ligand

1,01

2,02

D

ZC3H12D

zinc finger CCCH-type containing 12D

1,01

2,01

D

C15orf48

chromosome 15 open reading frame 48

1,00

2,00

E

PM20D1

peptidase M20 domain containing 1

−2,63

−6,19

KRT79

keratin 79

−2,04

−4,13

GAL

galanin/GMAP prepropeptide

−2,02

−4,06

ELOVL3

ELOVL fatty acid elongase 3

−1,71

−3,26

CYP4F8

cytochrome P450, family 4, subfamily F, polypeptide 8

−1,64

−3,11

HAO2

hydroxyacid oxidase 2 (long chain)

−1,63

−3,10

FADS2

fatty acid desaturase 2

−1,49

−2,80

ANGPTL7

angiopoietin-like 7

−1,40

−2,63

D

CUX2

cut-like homeobox 2

−1,36

−2,56

PON3

paraoxonase 3

−1,35

−2,55

E

SGK2

serum/glucocorticoid regulated kinase 2

−1,32

−2,50

MSMB

microseminoprotein, beta-

−1,31

−2,47

E

FADS1

fatty acid desaturase 1

−1,30

−2,46

D

BPY2

basic charge, Y-linked, 2

−1,29

−2,45

FAR2

fatty acyl CoA reductase 2

−1,29

−2,44

D

MUC7

mucin 7, secreted

−1,23

−2,35

FA2H

fatty acid 2-hydroxylase

−1,20

−2,30

ABHD12B

abhydrolase domain containing 12B

−1,18

−2,27

E

PNPLA3

patatin-like phospholipase domain containing 3

−1,18

−2,27

E

ACOX2

acyl-CoA oxidase 2, branched chain

−1,11

−2,16

D

PSORS1C2

psoriasis susceptibility 1 candidate 2

−1,10

−2,15

E

KRT19

keratin 19

−1,08

−2,11

ATP6V1B1

ATPase, H+ transporting, lysosomal 56/58 kDa, V1 subunit B1

−1,07

−2,10

SCGB2B2

secretoglobin, family 2B, member 2

−1,07

−2,09

MOGAT1

monoacylglycerol O-acyltransferase 1

−1,07

−2,09

NSUN7

NOP2/Sun domain family, member 7

−1,07

−2,09

E

COCH

cochlin

−1,05

−2,07

E

IL20RA

interleukin 20 receptor, alpha

−1,05

−2,07

E

SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

−1,03

−2,05

D

RHPN2

rhophilin, Rho GTPase binding protein 2

−1,03

−2,05

AWAT1

acyl-CoA wax alcohol acyltransferase 1

−1,03

−2,04

TMC4

transmembrane channel-like 4

−1,03

−2,04

GPRC5A

G protein-coupled receptor, class C, group 5, member A

−1,02

−2,03

TRHDE-AS1

TRHDE antisense RNA 1

−1,02

−2,03

AQP5

aquaporin 5

−1,02

−2,03

LINC00663

long intergenic non-protein coding RNA 663

−1,02

−2,02

ZNF471

zinc finger protein 471

−1,01

−2,02

CYP2J2

cytochrome P450, family 2, subfamily J, polypeptide 2

−1,01

−2,02

E

MEGF10

multiple EGF-like-domains 10

−1,01

−2,01

FAXDC2

fatty acid hydroxylase domain containing 2

−1,00

−2,01

D

SLC13A2

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2

−1,00

−2,01