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Table 1 Integration-Driven Discovery (IDD) Genes in the MADAD transcriptome, with indication of compartmental allocation as defined by Esaki et al. [63]

From: Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways

Symbol Description logFC FC Layer
Up
COL6A6 collagen, type VI, alpha 6 2,08 4,22 D
CD1B CD1b molecule 1,84 3,57 D
SPRR1B small proline-rich protein 1B 1,68 3,20 E
CCL22 chemokine (C-C motif) ligand 22 1,65 3,13 D
MMP9 matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase) 1,51 2,84 D
IL13RA2 interleukin 13 receptor, alpha 2 1,46 2,74 D
CCL26 chemokine (C-C motif) ligand 26 1,37 2,59 D
SASH3 SAM and SH3 domain containing 3 1,35 2,56 D
IL36RN interleukin 36 receptor antagonist 1,35 2,55 E
CCL13 chemokine (C-C motif) ligand 13 1,27 2,41 D
KIAA1644 KIAA1644 1,26 2,39 D
IL12RB1 interleukin 12 receptor, beta 1 1,23 2,34 D
XCL2 chemokine (C motif) ligand 2 1,21 2,31 D
CCL5 chemokine (C-C motif) ligand 5 1,21 2,31 D
ADAMDEC1 ADAM-like, decysin 1 1,19 2,29 D
TIFAB TRAF-interacting protein with forkhead-associated domain, family member B 1,18 2,27 D
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 1,16 2,23 E
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1,15 2,22 D
FAM124B family with sequence similarity 124B 1,14 2,21 D
SLAMF8 SLAM family member 8 1,12 2,18 D
CXADR coxsackie virus and adenovirus receptor 1,12 2,17 E
GPSM3 G-protein signaling modulator 3 1,11 2,16 D
HCK hemopoietic cell kinase 1,09 2,13 D
LOC100288860 uncharacterized LOC100288860 1,09 2,12 E
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) 1,08 2,11 D
CD1E CD1e molecule 1,07 2,10 D
KLRK1 killer cell lectin-like receptor subfamily K, member 1 1,06 2,09 D
GBP1 guanylate binding protein 1, interferon-inducible 1,06 2,09  
IL23A interleukin 23, alpha subunit p19 1,05 2,08 D
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 1,05 2,07 D
C5orf20 chromosome 5 open reading frame 20 1,05 2,06 D
CCL8 chemokine (C-C motif) ligand 8 1,04 2,06 D
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1,04 2,06  
ACPP acid phosphatase, prostate 1,03 2,05 E
TRAT1 T cell receptor associated transmembrane adaptor 1 1,03 2,04 D
PTX3 pentraxin 3, long 1,03 2,04 D
CD48 CD48 molecule 1,03 2,04 D
FPR3 formyl peptide receptor 3 1,02 2,03 D
TGM3 transglutaminase 3 1,02 2,03 E
CXCL11 chemokine (C-X-C motif) ligand 11 1,02 2,03  
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 1,02 2,02 D
CD6 CD6 molecule 1,02 2,02 D
SELPLG selectin P ligand 1,01 2,02 D
ZC3H12D zinc finger CCCH-type containing 12D 1,01 2,01 D
C15orf48 chromosome 15 open reading frame 48 1,00 2,00 E
Down
PM20D1 peptidase M20 domain containing 1 −2,63 −6,19  
KRT79 keratin 79 −2,04 −4,13  
GAL galanin/GMAP prepropeptide −2,02 −4,06  
ELOVL3 ELOVL fatty acid elongase 3 −1,71 −3,26  
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 −1,64 −3,11  
HAO2 hydroxyacid oxidase 2 (long chain) −1,63 −3,10  
FADS2 fatty acid desaturase 2 −1,49 −2,80  
ANGPTL7 angiopoietin-like 7 −1,40 −2,63 D
CUX2 cut-like homeobox 2 −1,36 −2,56  
PON3 paraoxonase 3 −1,35 −2,55 E
SGK2 serum/glucocorticoid regulated kinase 2 −1,32 −2,50  
MSMB microseminoprotein, beta- −1,31 −2,47 E
FADS1 fatty acid desaturase 1 −1,30 −2,46 D
BPY2 basic charge, Y-linked, 2 −1,29 −2,45  
FAR2 fatty acyl CoA reductase 2 −1,29 −2,44 D
MUC7 mucin 7, secreted −1,23 −2,35  
FA2H fatty acid 2-hydroxylase −1,20 −2,30  
ABHD12B abhydrolase domain containing 12B −1,18 −2,27 E
PNPLA3 patatin-like phospholipase domain containing 3 −1,18 −2,27 E
ACOX2 acyl-CoA oxidase 2, branched chain −1,11 −2,16 D
PSORS1C2 psoriasis susceptibility 1 candidate 2 −1,10 −2,15 E
KRT19 keratin 19 −1,08 −2,11  
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58 kDa, V1 subunit B1 −1,07 −2,10  
SCGB2B2 secretoglobin, family 2B, member 2 −1,07 −2,09  
MOGAT1 monoacylglycerol O-acyltransferase 1 −1,07 −2,09  
NSUN7 NOP2/Sun domain family, member 7 −1,07 −2,09 E
COCH cochlin −1,05 −2,07 E
IL20RA interleukin 20 receptor, alpha −1,05 −2,07 E
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B −1,03 −2,05 D
RHPN2 rhophilin, Rho GTPase binding protein 2 −1,03 −2,05  
AWAT1 acyl-CoA wax alcohol acyltransferase 1 −1,03 −2,04  
TMC4 transmembrane channel-like 4 −1,03 −2,04  
GPRC5A G protein-coupled receptor, class C, group 5, member A −1,02 −2,03  
TRHDE-AS1 TRHDE antisense RNA 1 −1,02 −2,03  
AQP5 aquaporin 5 −1,02 −2,03  
LINC00663 long intergenic non-protein coding RNA 663 −1,02 −2,02  
ZNF471 zinc finger protein 471 −1,01 −2,02  
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 −1,01 −2,02 E
MEGF10 multiple EGF-like-domains 10 −1,01 −2,01  
FAXDC2 fatty acid hydroxylase domain containing 2 −1,00 −2,01 D
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 −1,00 −2,01