Skip to main content

Table 2 MTGDR robust classifier genes, compared to treatment response, and indication of compartmental allocation as defined by Esaki et al. [63]

From: Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways

SYMBOL

LAYER

logFCH (MAD-AD)

logFCH (Dupilumab, 300 mg, W4)

logFCH (Cyclosporin, W2)

logFCH (Cyclosporin, W12)

logFCH (UVB, W12)

Genename

Recovery (Dupilumab, 300 mg, W4)

Recovery (Cyclosporin, W2)

Recovery (Cyclosporin, W12)

Recovery (UVB, W12)

IGFL1

E

3.5

−2.4a

−2.6a

−3.6a

−2.3a

IGF-like family member 1

68.60

74.81

101.60

64.33

OASL

D

2.9

−2.7a

−2.7a

−3.3a

−1.8a

2'-5'-oligoadenylate synthetase-like

93.07

93.24

112.20

60.33

SELE

D

2.4

−2.9a

−1.6a

−1.6a

−2.3a

selectin E

121.06

66.99

66.24

94.94

AKR1B10

E

3.2

−1.3

−3.2a

−4.0a

−3.0a

aldo-keto reductase family 1, member B10 (aldose reductase)

42.39

100.29

127.48

95.22

MS4A14

D

1.4

−2.0a

−1.2a

−1.4a

0.0

membrane-spanning 4-domains, subfamily A, member 14

149.43

84.71

102.42

0.00

NUF2

E

1.4

−2.2a

−1.4a

−1.4a

−0.9

NUF2, NDC80 kinetochore complex component

155.33

96.79

96.65

59.46

S100A9

E

3.8

−1.1

−3.7a

−4.5a

−2.2a

S100 calcium binding protein A9

27.95

96.75

116.47

57.26

SERPINB3

E

3.8

−1.9

−3.2a

−3.8a

−2.4a

serpin peptidase inhibitor, clade B (ovalbumin), member 3

50.29

85.47

101.40

62.98

C15orf48

E

1.0

−0.9

−1.0

−1.3a

−2.1a

chromosome 15 open reading frame 48

93.70

103.85

131.53

211.69

MMP3

D

1.1

−4.0a

−2.0a

−0.9

−0.3

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

374.65

181.39

81.06

25.91

MUC7

 

−1.2

−0.1

0.0

0.0

1.1

mucin 7, secreted

−9.82

0.00

0.00

87.60

HSPB7

D

−1.6

1.6

0.6

1.7a

0.2

heat shock 27 kDa protein family, member 7 (cardiovascular)

102.98

37.95

107.88

13.51

SCGB1D2

D

−1.2

0.3

0.5

1.2a

0.0

secretoglobin, family 1D, member 2

25.96

43.28

100.97

0.00

BTC

E

−2.1

−0.1

1.0

1.3a

1.3a

betacellulin

−6.53

48.15

65.56

65.17

CIDEC

 

−1.7

2.1

1.2a

1.8a

0.0

cell death-inducing DFFA-like effector c

126.22

72.11

106.23

−2.38

HSD11B1

E

−2.3

−1.8

0.1

2.1a

1.0a

hydroxysteroid (11-beta) dehydrogenase 1

−77.60

5.69

91.93

44.65

PLIN1

 

−1.9

1.9

1.7a

2.0a

0.3

perilipin 1

98.89

85.20

103.82

12.83

SCGB2A1

D

−1.8

−0.1

0.9

1.7a

1.5a

secretoglobin, family 2A, member 1

−7.33

50.36

92.70

80.79

WIF1

D

−2.2

0.7

1.2

2.1a

1.3a

WNT inhibitory factor 1

29.58

52.56

92.11

58.40

E = Epidermis, D = Dermis (Esaki et al. [63])

 

Average

76.78

72.61

94.64

57.51

  1. aIndicate FDR ≤ 0.05