Skip to main content

Table 2 MTGDR robust classifier genes, compared to treatment response, and indication of compartmental allocation as defined by Esaki et al. [63]

From: Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways

SYMBOL LAYER logFCH (MAD-AD) logFCH (Dupilumab, 300 mg, W4) logFCH (Cyclosporin, W2) logFCH (Cyclosporin, W12) logFCH (UVB, W12) Genename Recovery (Dupilumab, 300 mg, W4) Recovery (Cyclosporin, W2) Recovery (Cyclosporin, W12) Recovery (UVB, W12)
IGFL1 E 3.5 −2.4a −2.6a −3.6a −2.3a IGF-like family member 1 68.60 74.81 101.60 64.33
OASL D 2.9 −2.7a −2.7a −3.3a −1.8a 2'-5'-oligoadenylate synthetase-like 93.07 93.24 112.20 60.33
SELE D 2.4 −2.9a −1.6a −1.6a −2.3a selectin E 121.06 66.99 66.24 94.94
AKR1B10 E 3.2 −1.3 −3.2a −4.0a −3.0a aldo-keto reductase family 1, member B10 (aldose reductase) 42.39 100.29 127.48 95.22
MS4A14 D 1.4 −2.0a −1.2a −1.4a 0.0 membrane-spanning 4-domains, subfamily A, member 14 149.43 84.71 102.42 0.00
NUF2 E 1.4 −2.2a −1.4a −1.4a −0.9 NUF2, NDC80 kinetochore complex component 155.33 96.79 96.65 59.46
S100A9 E 3.8 −1.1 −3.7a −4.5a −2.2a S100 calcium binding protein A9 27.95 96.75 116.47 57.26
SERPINB3 E 3.8 −1.9 −3.2a −3.8a −2.4a serpin peptidase inhibitor, clade B (ovalbumin), member 3 50.29 85.47 101.40 62.98
C15orf48 E 1.0 −0.9 −1.0 −1.3a −2.1a chromosome 15 open reading frame 48 93.70 103.85 131.53 211.69
MMP3 D 1.1 −4.0a −2.0a −0.9 −0.3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) 374.65 181.39 81.06 25.91
MUC7   −1.2 −0.1 0.0 0.0 1.1 mucin 7, secreted −9.82 0.00 0.00 87.60
HSPB7 D −1.6 1.6 0.6 1.7a 0.2 heat shock 27 kDa protein family, member 7 (cardiovascular) 102.98 37.95 107.88 13.51
SCGB1D2 D −1.2 0.3 0.5 1.2a 0.0 secretoglobin, family 1D, member 2 25.96 43.28 100.97 0.00
BTC E −2.1 −0.1 1.0 1.3a 1.3a betacellulin −6.53 48.15 65.56 65.17
CIDEC   −1.7 2.1 1.2a 1.8a 0.0 cell death-inducing DFFA-like effector c 126.22 72.11 106.23 −2.38
HSD11B1 E −2.3 −1.8 0.1 2.1a 1.0a hydroxysteroid (11-beta) dehydrogenase 1 −77.60 5.69 91.93 44.65
PLIN1   −1.9 1.9 1.7a 2.0a 0.3 perilipin 1 98.89 85.20 103.82 12.83
SCGB2A1 D −1.8 −0.1 0.9 1.7a 1.5a secretoglobin, family 2A, member 1 −7.33 50.36 92.70 80.79
WIF1 D −2.2 0.7 1.2 2.1a 1.3a WNT inhibitory factor 1 29.58 52.56 92.11 58.40
E = Epidermis, D = Dermis (Esaki et al. [63])   Average 76.78 72.61 94.64 57.51
  1. aIndicate FDR ≤ 0.05