Fig. 4

To identify the microRNAs with the greatest functional impact on fibrosis, we examined which microRNAs show the greatest difference in sequencing reads between diseased Dupuytren’s fascia and control fascia regardless of fold change. This analysis, comparing all statistically significant differentially expressed microRNAs with an average expression greater than 100 normalized reads, shows that a small subset of differentially expressed microRNAs account for the majority of sequencing reads. These microRNAs, which show the greatest change in abundance, may potentially make the greatest functional contribution to the phenotypic differences observed between Dupuytren’s fascia and non-diseased fascia