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Fig. 5 | BMC Medical Genomics

Fig. 5

From: RNA sequencing reveals a depletion of collagen targeting microRNAs in Dupuytren’s disease

Fig. 5

A venn diagram showing a comparison of microRNAs upregulated (fold change > 2) in patient matched Dupuytren’s fascia and adjacent fascia biopsies. It is notable that there are no microRNAs commonly upregulated in any of the patient matched biopsies in either the Dupuytren’s or the adjacent fascia, highlighting the heterogeneity (Dupuytren’s vs control phenotype) of the adjacent fascia biopsies. During unsupervised hierarchical clustering analysis (Fig. 2) specimen “a” preferentially clustered with Dupuytren’s fascia, thus intraoperative examination of surgical tissue may not be able to reliably differentiate between diseased and non-diseased fascia at the molecular level. It is notable that adjacent fascia specimens “b” and “c”, which cluster with control fascia, both show enrichment in known collagen targeting microRNAs (highlighted in grey), which are depleted in specimen “A”

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