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Fig. 8 | BMC Medical Genomics

Fig. 8

From: RNA sequencing reveals a depletion of collagen targeting microRNAs in Dupuytren’s disease

Fig. 8

A RT-qPCR screen for fibrosis associated mRNAs linked to Wnt and TGFβ signaling are shown. This analysis reveals a statistically significant upregulation of WNT5A in Dupuytren’s fascia, and a paradoxical upregulation of TGFBR2 in control fascia. WNT5A is predicted to be downregulated by microRNAs enriched in Dupuytren’s disease based on ComiR analysis, thus WNT5A upregulation is unlikely to be mediated solely by microRNA regulatory. In accordance with ComiR target predictions, we do not observe strong evidence for direct microRNA regulation of TGFβ and Wnt signaling pathways in Dupuytren’s disease

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