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Table 2 Collagens targeted by microRNAs enriched in control palmar fascia - ComiR target prediction shows that the majority of collagens are preferentially inhibited by microRNAs enriched in control fascia compared with Dupuytren’s fascia. In our analysis of collagen expression using RT-qPCR, COL8A1 and COL15A1 were the only collagens that did not show a statistically significant increase in Dupuytren’s fascia. Notably these collagens also exhibited the lowest degree of microRNA targeting

From: RNA sequencing reveals a depletion of collagen targeting microRNAs in Dupuytren’s disease

GENE ID ComiR score difference (Control Fascia –Dupuytren’s Fascia) p-value
COL5A3 0.0896 0.0007
COL1A2 0.0804 <0.001
COL4A2 0.0630 <0.001
COL11A1 0.0602 <0.001
COL3A1 0.0543 <0.001
COL5A1 0.0472 0.0015
COL18A1 0.0469 0.0033
COL1A1 0.0431 <0.001
COL13A1 0.0407 0.0488
COL21A1 0.0387 <0.001
COL15A1 0.0386 0.0005
COL5A2 0.0381 0.0006
COL7A1 0.0344 <0.001
COL12A1 0.0330 0.0749
COL16A1 0.0192 0.0028
COL4A4 −0.0031 0.1286
COL27A1 −0.0103 0.3310
COL8A1 −0.0136 0.1502
COL2A1 −0.0186 0.0141
COL4A1 −0.0187 0.3535
COL6A1 −0.0238 0.0715
COL6A3 −0.0245 0.0523
COL8A2 −0.0463 <0.001
COL6A2 −0.1577 <0.001