Skip to main content

Table 2 Collagens targeted by microRNAs enriched in control palmar fascia - ComiR target prediction shows that the majority of collagens are preferentially inhibited by microRNAs enriched in control fascia compared with Dupuytren’s fascia. In our analysis of collagen expression using RT-qPCR, COL8A1 and COL15A1 were the only collagens that did not show a statistically significant increase in Dupuytren’s fascia. Notably these collagens also exhibited the lowest degree of microRNA targeting

From: RNA sequencing reveals a depletion of collagen targeting microRNAs in Dupuytren’s disease

GENE ID

ComiR score difference (Control Fascia –Dupuytren’s Fascia)

p-value

COL5A3

0.0896

0.0007

COL1A2

0.0804

<0.001

COL4A2

0.0630

<0.001

COL11A1

0.0602

<0.001

COL3A1

0.0543

<0.001

COL5A1

0.0472

0.0015

COL18A1

0.0469

0.0033

COL1A1

0.0431

<0.001

COL13A1

0.0407

0.0488

COL21A1

0.0387

<0.001

COL15A1

0.0386

0.0005

COL5A2

0.0381

0.0006

COL7A1

0.0344

<0.001

COL12A1

0.0330

0.0749

COL16A1

0.0192

0.0028

COL4A4

−0.0031

0.1286

COL27A1

−0.0103

0.3310

COL8A1

−0.0136

0.1502

COL2A1

−0.0186

0.0141

COL4A1

−0.0187

0.3535

COL6A1

−0.0238

0.0715

COL6A3

−0.0245

0.0523

COL8A2

−0.0463

<0.001

COL6A2

−0.1577

<0.001