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Fig. 3 | BMC Medical Genomics

Fig. 3

From: High metallothionein predicts poor survival in glioblastoma multiforme

Fig. 3

a p53 conformation is inactive in U251 cell line. Fluorescent microscope image with 4× objective of U251 cells stained with DAPI for nuclei (blue) and FITC (green) Ab for wild type (WT) p53 (PAb1620) or FITC Ab for Mutant (MT) p53 (PAb240). b p53 conformation in U87 cell line changes to active form upon zinc addition. Untreated /zinc treated superimposed fluorescent microscope image with 10× objective of U87 stained with DAPI for nuclei (blue) and FITC (green) Ab for wild type (WT) p53 (PAb1620) or FITC Ab for Mutant (MT) p53 (PAb240). After zinc supplementation in U87 cells, p53 conformation changed from inactive mutant like to active WT like

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