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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Systems biology evaluation of cell-free amniotic fluid transcriptome of term and preterm infants to detect fetal maturity

Fig. 4

Differentially expressed genes in Term versus Late Preterm AF samples. a This heatmap depicts the 257 genes that were significantly differentially expressed in Late Preterm versus Term samples. b, c Functional enrichment analysis revealed distinct biological processes and pathways associated with genes differentially expressed in Late Preterm versus Term (b = enriched in full term infants, c = enriched in late preterm infants). d The top 60 significantly changed genes in Term versus Late Preterm. P-value is calculated by student T-test with Benjamini–Hochberg FDR correction (Benjamini Yoav, Hochberg Yosef. Controlling the false discovery rate: A practical and powerful approach to multiple testing. JRSS-B. 1995;57(1):289–300). Gene set functional enrichment analysis was performed using Toppgene suite (https://toppgene.cchmc.org/). The transcription factor notations reflect the type of position-specific scoring matrix used (e.g., V$ for vertebrate matrix library)

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