Skip to main content
Fig. 4 | BMC Medical Genomics

Fig. 4

From: Gene expression profiling of the human natural killer cell response to Fc receptor activation: unique enhancement in the presence of interleukin-12

Fig. 4

Genes uniquely regulated in NK cells following FcR activation in the presence of IL-12 grouped by function. Gene expression values of genes differentially expressed by at least 2-fold by NK cells stimulated by immobilized IgG plus IL-12 vs. those stimulated by Medium. Bars represent fold change of the mRNA level of a particular gene when comparing the subpopulations. Positive values indicate that the transcript was more abundant in the stimulated cells and negative values indicate that the gene was down-regulated in the stimulated cells. Genes were grouped according to their presumed function (a-e) based on information available in public databases or in the literature (see Materials and Methods). f Validation of microarray gene expression estimates by Real-Time PCR. Shown is fold change in gene expression (vs. no stimulation) within NK cells following FcR activation (IgG), IL-12 stimulation (IL-12), or FcR activation in the presence of IL-12 (IgG plus IL-12). Representative data from a single donor out of three examined is shown for each gene listed on the right

Back to article page