Identification of potential mutations and genomic alterations in the epithelial and spindle cell components of biphasic synovial sarcomas using a human exome SNP chip

Table 3 Functional enrichment analysis of top ranked SNPs

Different riched methods	Related pathways of riched functional analysis	P value	Related genes of riched functional analysis
Wikipathways pathway	Inflammatory Response Pathway	0.0013	IL4R, LAMC2, LAMA5, COL1A1
	Focal Adhesion	0.0029	SPP1, COL1A1, COL5A1, EGF, TNXB, ROCK1, LAMC2, PIK3CG, LAMA5
	TGF Beta Signaling Pathway	0.0097	EP300, SPP1, JAK1, EGF
KEGG pathway	ECM-receptor interaction	0.0004	GP9, SPP1, LAMA5, LAMC2, COL1A1, COL5A1, TNXB
	Focal adhesion	0.0015	SPP1, FLT4, COL1A1, COL5A1, EGF, TNXB, ROCK1, LAMC2, LAMA5, PIK3CG
	Phenylalanine metabolism	0.0044	IL4I1, AOC2, ALDH3B2
	Jak-STAT signaling pathway	0.0063	IFNE, EP300, IL4R, IL11RA, JAK1, PIK3CG, CBLB
	Hematopoietic cell lineage	0.0085	CD1E, GP9, IL4R, IL11RA, CD22
	Inositol phosphate metabolism	0.0111	PLCB4, PIK3C2B, PIK3CG, PIK3C2A
Pathway Commons pathway	Intrinsic Pathway	0.0015	GP9, C1QBP, A2M, F13A1
	Formation of Fibrin Clot (Clotting Cascade)-	0.0021	GP9, C1QBP, A2M, F13A1
	Hemostasis	0.0054	TTN, OL1A1, A2M, EGF, F13A1, GP9, MAG, C1QBP
	Platelet Activation	0.0054	GP9, COL1A1, A2M, EGF, F13A1
	Exocytosis of Alpha granule	0.0050	GP9, A2M, EGF, F13A1
	Platelet degranulation	0.0059	GP9, A2M, EGF, F13A1
	Terminal pathway of complement	0.0037	C8G, C7
	vWF interaction with collagen	0.0037	GP9, COL1A1