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Fig. 1 | BMC Medical Genomics

Fig. 1

From: MiRNA profiling of whole trabecular bone: identification of osteoporosis-related changes in MiRNAs in human hip bones

Fig. 1

a PCA plot and (b) heat map diagram. Principal component analysis and clustering was performed on all samples and on the top 50 microRNAs with the highest standard deviation. Normalized log ratio values were used for the analysis. a Before the analysis, the features were shifted to be zero centered and scaled to unit variance. b Diagram shows the result of a two-way hierarchical clustering of microRNAs and samples. The clustering is done using the complete-linkage method together with the Euclidean distance. Each row represents a microRNA and each column, a sample. The microRNA clustering tree is shown on the left. The colour scale illustrates the relative level of microRNA expression: red, below the reference channel; green, higher than the reference

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