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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Histone methylation levels correlate with TGFBIp and extracellular matrix gene expression in normal and granular corneal dystrophy type 2 corneal fibroblasts

Fig. 4

TGFβ1 enhanced Smad3 recruitment to the TGFBIp and ECM-associated gene promoters. Smad3 recruitment at the indicated gene promoters in wild-type and GCD2 homozygous corneal fibroblasts was stimulated by TGFβ1 (5 ng/ml) for 8 h. Smad3 recruitment was determined by ChIP assays with Smad3 antibody. Results were normalized to the input, and Smad3 occupancy was expressed as the fold enrichment over respective wild-type control samples (mean ± standard error (SE); **P < 0.01 vs. wild type, n = 3)

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BMC Medical Genomics

ISSN: 1755-8794

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