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Table 2 Clinico-pathological characteristics according to the three patients’ age groups of the whole cohort

From: Gene-expression signature functional annotation of breast cancer tumours in function of age

Patients’ group (years and [n])

n 2378

≤40 (n = 345)

40 < x < 70 (n = 1667)

≥70 (n = 366)

p-value

Age (years)

      
 

Median (IQR)

54 (45–64)

37 (34–39)

54 (47–61)

74 (72–80)

 

ER status

      
 

Positive

1671 (71 %)

199 (58 %)

1170 (71 %)

302 (83 %)

<0.0001

 

Negative

681 (29 %)

143 (42 %)

477 (29 %)

61 (17 %)

 

HER2 status

      
 

Positive

136 (14 %)

28 (19 %)

89 (13 %)

19 (17 %)

0.4862

 

Negative

808 (86 %)

121 (81 %)

592 (87 %)

95 (83 %)

 

Nodal status

      
 

Positive

882 (43 %)

130 (49 %)

603 (42 %)

149 (44 %)

0.4010

 

Negative

1172 (57 %)

138 (51 %)

847 (58 %)

187 (56 %)

 

SBR grade

      
 

1

302 (17 %)

15 (6 %)

223 (17 %)

64 (22 %)

<0.0001

 

2

770 (42 %)

83 (36 %)

561 (44 %)

126 (43 %)

 
 

3

742 (41 %)

134 (58 %)

504 (39 %)

104 (35 %)

 

Tumour size

      
 

≤20 mm

626 (46 %)

57 (44 %)

458 (48 %)

111 (42 %)

0.3993

 

>20 mm

723 (54 %)

72 (56 %)

499 (52 %)

152 (58 %)

 
  1. Abbreviations: ER oestrogen receptor, IQR interquartile range, SBR Scarff-Bloom-Richardson histological grade