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Table 2 Clinico-pathological characteristics according to the three patients’ age groups of the whole cohort

From: Gene-expression signature functional annotation of breast cancer tumours in function of age

Patients’ group (years and [n]) n 2378 ≤40 (n = 345) 40 < x < 70 (n = 1667) ≥70 (n = 366) p-value
Age (years)       
  Median (IQR) 54 (45–64) 37 (34–39) 54 (47–61) 74 (72–80)  
ER status       
  Positive 1671 (71 %) 199 (58 %) 1170 (71 %) 302 (83 %) <0.0001
  Negative 681 (29 %) 143 (42 %) 477 (29 %) 61 (17 %)  
HER2 status       
  Positive 136 (14 %) 28 (19 %) 89 (13 %) 19 (17 %) 0.4862
  Negative 808 (86 %) 121 (81 %) 592 (87 %) 95 (83 %)  
Nodal status       
  Positive 882 (43 %) 130 (49 %) 603 (42 %) 149 (44 %) 0.4010
  Negative 1172 (57 %) 138 (51 %) 847 (58 %) 187 (56 %)  
SBR grade       
  1 302 (17 %) 15 (6 %) 223 (17 %) 64 (22 %) <0.0001
  2 770 (42 %) 83 (36 %) 561 (44 %) 126 (43 %)  
  3 742 (41 %) 134 (58 %) 504 (39 %) 104 (35 %)  
Tumour size       
  ≤20 mm 626 (46 %) 57 (44 %) 458 (48 %) 111 (42 %) 0.3993
  >20 mm 723 (54 %) 72 (56 %) 499 (52 %) 152 (58 %)  
  1. Abbreviations: ER oestrogen receptor, IQR interquartile range, SBR Scarff-Bloom-Richardson histological grade