From: Gene-expression signature functional annotation of breast cancer tumours in function of age
GES name | Whole cohort | Caucasian cohort | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 | p-value |  | p-value |  | Results |  | p-value |  | p-value |  | Results |  |
 |  | 1 vs 2 | 1 vs 3 | 2 vs 3 |  |  |  | 1 vs 2 | 1 vs 3 | 2 vs 3 |  |  |
Molecular subtyping | Â | |||||||||||
 ER | <0.0001 | <0.0001 | <0.0001 | 0.0014 | 1 < 2 < 3 |  | <0.0001 | <0.0001 | <0.0001 | 0.0096 | 1 < 2 < 3 |  |
 Molecular-apocrine | <0.0001 | <0.0001 | <0.0001 | 0.3376 | 1 < 2 ≈ 3 |  | <0.0001 | <0.0001 | <0.0001 | 0.5479 | 1 < 2 ≈ 3 |  |
 Basal-like | <0.0001 | <0.0001 | <0.0001 | <0.0001 | 1 > 2 > 3 |  | <0.0001 | <0.0001 | <0.0001 | 0.0006 | 1 > 2 > 3 |  |
 Claudin-CD24 | 0.8457 |  |  |  | NS |  | 0.9813 |  |  |  | NS |  |
Immune response | Â | |||||||||||
 B-cell | <0.0001 | 0.7488 | <0.0001 | <0.0001 | 1 ≈ 2 > 3 |  | 0.0001 | 0.9398 | 0.0053 | 0.0001 | 1 ≈ 2 > 3 |  |
 T-cell | 0.0016 | 0.7797 | 0.0667 | 0.0010 | 2 > 3 | 1 ≈ 2 and 1 ≈ 3 | 0.0204 | 0.9736 | 0.1891 | 0.0153 | 2 > 3 | 1 ≈ 2 and 1 ≈ 3 |
 MHC-1 | 0.0175 | 0.8578 | 0.0368 | 0.0215 | 1 ≈ 2 > 3 |  | 0.0300 | 0.6309 | 0.0471 | 0.0589 | 1 > 3 | 1 ≈ 2 and 2 ≈ 3 |
 MHC-2 | 0.0133 | 0.0616 | 0.9987 | 0.0623 | NS |  | 0.0486 | 0.1769 | 0.9901 | 0.1133 | NS |  |
 M2/M1 | 0.0136 | 0.3213 | 0.0113 | 0.0616 | 1 < 3 | 1 ≈ 2 and 2 ≈ 3 | 0.0429 | 0.2421 | 0.0341 | 0.2445 | 1 < 3 | 1 ≈ 2 and 2 ≈ 3 |
 IFN | 0.0067 | 0.3113 | 0.0059 | 0.0326 | 1 ≈ 2 > 3 |  | 0.0633 |  |  |  | NS |  |
 IL-8 | 0.0004 | 0.0091 | 0.0003 | 0.0917 | 1 > 2 ≈ 3 |  | <0.0001 | <0.0001 | <0.0001 | 0.3518 | 1 > 2 ≈ 3 |  |
Metabolism | Â | |||||||||||
 Adipocytes | 0.0118 | 0.0140 | 0.5359 | 0.2931 | 1 < 2 | 1 ≈ 3 and 2 ≈ 3 | 0.2272 |  |  |  | NS |  |
 Glycolysis | 0.0044 | 0.1734 | 0.0032 | 0.0418 | 1 ≈ 2 > 3 |  | 0.0037 | 0.0112 | 0.0031 | 0.4653 | 1 > 2 ≈ 3 |  |
 IRGS | 0.0013 | 0.0012 | 0.0047 | 0.9587 | 1 > 2 ≈ 3 |  | 0.0122 | 0.0458 | 0.0085 | 0.3879 | 1 > 2 ≈ 3 |  |
Critical biological pathways in cancer | Â | |||||||||||
 CIN | <0.0001 | <0.0001 | 0.0003 | 0.9997 | 1 > 2 ≈ 3 |  | <0.0001 | <0.0001 | 0.0012 | 0.7143 | 1 > 2 ≈ 3 |  |
 ERBB2 | 0.0771 |  |  |  | NS |  | 0.0473 | 0.9297 | 0.1280 | 0.0506 | NS |  |
 HOXA | 0.7895 |  |  |  | NS |  | 0.5566 |  |  |  | NS |  |
 MITO/OXPHOS | <0.0001 | 0.2278 | <0.0001 | 0.0006 | 1 ≈ 2 < 3 |  | 0.0013 | 0.8029 | 0.0097 | 0.0018 | 1 ≈ 2 < 3 |  |
 Proliferation | <0.0001 | <0.0001 | 0.0003 | 0.9989 | 1 > 2 ≈ 3 |  | <0.0001 | <0.0001 | 0.0013 | 0.9542 | 1 > 2 ≈ 3 |  |
 Reactive stroma | <0.0001 | 0.1912 | 0.0487 | <0.0001 | 1 ≈ 2 > 3 |  | 0.0001 | 0.1684 | 0.3841 | 0.0001 | 2 > 3 | 1 ≈ 2 and 1 ≈ 3 |
 VEGF | 0.4340 |  |  |  | NS |  | 0.0743 |  |  |  | NS |  |
Prognosis | Â | |||||||||||
 70-GES | <0.0001 | <0.0001 | 0.0001 | 0.9441 | 1 > 2 ≈ 3 |  | <0.0001 | <0.0001 | <0.0001 | 0.9839 | 1 > 2 ≈ 3 |  |
 GGI | <0.0001 | <0.0001 | 0.0008 | 0.9303 | 1 > 2 ≈ 3 |  | 0.0004 | 0.0003 | 0.0031 | 0.9902 | 1 > 2 ≈ 3 |  |
 RS | <0.0001 | <0.0001 | <0.0001 | 0.0006 | 1 > 2 > 3 |  | <0.0001 | <0.0001 | <0.0001 | 0.0183 | 1 > 2 > 3 |  |