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Table 4 Continuous GES analyses interpretation in function of three age groups

From: Gene-expression signature functional annotation of breast cancer tumours in function of age

GES name

Whole cohort

Caucasian cohort

 

p-value

 

p-value

 

Results

 

p-value

 

p-value

 

Results

 
  

1 vs 2

1 vs 3

2 vs 3

   

1 vs 2

1 vs 3

2 vs 3

  

Molecular subtyping

 

 ER

<0.0001

<0.0001

<0.0001

0.0014

1 < 2 < 3

 

<0.0001

<0.0001

<0.0001

0.0096

1 < 2 < 3

 

 Molecular-apocrine

<0.0001

<0.0001

<0.0001

0.3376

1 < 2 ≈ 3

 

<0.0001

<0.0001

<0.0001

0.5479

1 < 2 ≈ 3

 

 Basal-like

<0.0001

<0.0001

<0.0001

<0.0001

1 > 2 > 3

 

<0.0001

<0.0001

<0.0001

0.0006

1 > 2 > 3

 

 Claudin-CD24

0.8457

   

NS

 

0.9813

   

NS

 

Immune response

 

 B-cell

<0.0001

0.7488

<0.0001

<0.0001

1 ≈ 2 > 3

 

0.0001

0.9398

0.0053

0.0001

1 ≈ 2 > 3

 

 T-cell

0.0016

0.7797

0.0667

0.0010

2 > 3

1 ≈ 2 and 1 ≈ 3

0.0204

0.9736

0.1891

0.0153

2 > 3

1 ≈ 2 and 1 ≈ 3

 MHC-1

0.0175

0.8578

0.0368

0.0215

1 ≈ 2 > 3

 

0.0300

0.6309

0.0471

0.0589

1 > 3

1 ≈ 2 and 2 ≈ 3

 MHC-2

0.0133

0.0616

0.9987

0.0623

NS

 

0.0486

0.1769

0.9901

0.1133

NS

 

 M2/M1

0.0136

0.3213

0.0113

0.0616

1 < 3

1 ≈ 2 and 2 ≈ 3

0.0429

0.2421

0.0341

0.2445

1 < 3

1 ≈ 2 and 2 ≈ 3

 IFN

0.0067

0.3113

0.0059

0.0326

1 ≈ 2 > 3

 

0.0633

   

NS

 

 IL-8

0.0004

0.0091

0.0003

0.0917

1 > 2 ≈ 3

 

<0.0001

<0.0001

<0.0001

0.3518

1 > 2 ≈ 3

 

Metabolism

 

 Adipocytes

0.0118

0.0140

0.5359

0.2931

1 < 2

1 ≈ 3 and 2 ≈ 3

0.2272

   

NS

 

 Glycolysis

0.0044

0.1734

0.0032

0.0418

1 ≈ 2 > 3

 

0.0037

0.0112

0.0031

0.4653

1 > 2 ≈ 3

 

 IRGS

0.0013

0.0012

0.0047

0.9587

1 > 2 ≈ 3

 

0.0122

0.0458

0.0085

0.3879

1 > 2 ≈ 3

 

Critical biological pathways in cancer

 

 CIN

<0.0001

<0.0001

0.0003

0.9997

1 > 2 ≈ 3

 

<0.0001

<0.0001

0.0012

0.7143

1 > 2 ≈ 3

 

 ERBB2

0.0771

   

NS

 

0.0473

0.9297

0.1280

0.0506

NS

 

 HOXA

0.7895

   

NS

 

0.5566

   

NS

 

 MITO/OXPHOS

<0.0001

0.2278

<0.0001

0.0006

1 ≈ 2 < 3

 

0.0013

0.8029

0.0097

0.0018

1 ≈ 2 < 3

 

 Proliferation

<0.0001

<0.0001

0.0003

0.9989

1 > 2 ≈ 3

 

<0.0001

<0.0001

0.0013

0.9542

1 > 2 ≈ 3

 

 Reactive stroma

<0.0001

0.1912

0.0487

<0.0001

1 ≈ 2 > 3

 

0.0001

0.1684

0.3841

0.0001

2 > 3

1 ≈ 2 and 1 ≈ 3

 VEGF

0.4340

   

NS

 

0.0743

   

NS

 

Prognosis

 

 70-GES

<0.0001

<0.0001

0.0001

0.9441

1 > 2 ≈ 3

 

<0.0001

<0.0001

<0.0001

0.9839

1 > 2 ≈ 3

 

 GGI

<0.0001

<0.0001

0.0008

0.9303

1 > 2 ≈ 3

 

0.0004

0.0003

0.0031

0.9902

1 > 2 ≈ 3

 

 RS

<0.0001

<0.0001

<0.0001

0.0006

1 > 2 > 3

 

<0.0001

<0.0001

<0.0001

0.0183

1 > 2 > 3

 
  1. 1: ≤ 40 years; 2: 40 < x < 70 years; 3: ≥ 70 years; ER oestrogen receptor, IFN interferon, IRGS iron regulatory gene signature, CIN chromosomal instability, MITO/OXPHOS mitochondrial oxidative phosphorylation, NS not significant (p > 0.05), 70-GES van’t Veer and colleagues prognostic GES, GGI genomic grade index, RS recurrence score