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Table 4 Continuous GES analyses interpretation in function of three age groups

From: Gene-expression signature functional annotation of breast cancer tumours in function of age

GES name Whole cohort Caucasian cohort
  p-value   p-value   Results   p-value   p-value   Results  
   1 vs 2 1 vs 3 2 vs 3     1 vs 2 1 vs 3 2 vs 3   
Molecular subtyping  
 ER <0.0001 <0.0001 <0.0001 0.0014 1 < 2 < 3   <0.0001 <0.0001 <0.0001 0.0096 1 < 2 < 3  
 Molecular-apocrine <0.0001 <0.0001 <0.0001 0.3376 1 < 2 ≈ 3   <0.0001 <0.0001 <0.0001 0.5479 1 < 2 ≈ 3  
 Basal-like <0.0001 <0.0001 <0.0001 <0.0001 1 > 2 > 3   <0.0001 <0.0001 <0.0001 0.0006 1 > 2 > 3  
 Claudin-CD24 0.8457     NS   0.9813     NS  
Immune response  
 B-cell <0.0001 0.7488 <0.0001 <0.0001 1 ≈ 2 > 3   0.0001 0.9398 0.0053 0.0001 1 ≈ 2 > 3  
 T-cell 0.0016 0.7797 0.0667 0.0010 2 > 3 1 ≈ 2 and 1 ≈ 3 0.0204 0.9736 0.1891 0.0153 2 > 3 1 ≈ 2 and 1 ≈ 3
 MHC-1 0.0175 0.8578 0.0368 0.0215 1 ≈ 2 > 3   0.0300 0.6309 0.0471 0.0589 1 > 3 1 ≈ 2 and 2 ≈ 3
 MHC-2 0.0133 0.0616 0.9987 0.0623 NS   0.0486 0.1769 0.9901 0.1133 NS  
 M2/M1 0.0136 0.3213 0.0113 0.0616 1 < 3 1 ≈ 2 and 2 ≈ 3 0.0429 0.2421 0.0341 0.2445 1 < 3 1 ≈ 2 and 2 ≈ 3
 IFN 0.0067 0.3113 0.0059 0.0326 1 ≈ 2 > 3   0.0633     NS  
 IL-8 0.0004 0.0091 0.0003 0.0917 1 > 2 ≈ 3   <0.0001 <0.0001 <0.0001 0.3518 1 > 2 ≈ 3  
Metabolism  
 Adipocytes 0.0118 0.0140 0.5359 0.2931 1 < 2 1 ≈ 3 and 2 ≈ 3 0.2272     NS  
 Glycolysis 0.0044 0.1734 0.0032 0.0418 1 ≈ 2 > 3   0.0037 0.0112 0.0031 0.4653 1 > 2 ≈ 3  
 IRGS 0.0013 0.0012 0.0047 0.9587 1 > 2 ≈ 3   0.0122 0.0458 0.0085 0.3879 1 > 2 ≈ 3  
Critical biological pathways in cancer  
 CIN <0.0001 <0.0001 0.0003 0.9997 1 > 2 ≈ 3   <0.0001 <0.0001 0.0012 0.7143 1 > 2 ≈ 3  
 ERBB2 0.0771     NS   0.0473 0.9297 0.1280 0.0506 NS  
 HOXA 0.7895     NS   0.5566     NS  
 MITO/OXPHOS <0.0001 0.2278 <0.0001 0.0006 1 ≈ 2 < 3   0.0013 0.8029 0.0097 0.0018 1 ≈ 2 < 3  
 Proliferation <0.0001 <0.0001 0.0003 0.9989 1 > 2 ≈ 3   <0.0001 <0.0001 0.0013 0.9542 1 > 2 ≈ 3  
 Reactive stroma <0.0001 0.1912 0.0487 <0.0001 1 ≈ 2 > 3   0.0001 0.1684 0.3841 0.0001 2 > 3 1 ≈ 2 and 1 ≈ 3
 VEGF 0.4340     NS   0.0743     NS  
Prognosis  
 70-GES <0.0001 <0.0001 0.0001 0.9441 1 > 2 ≈ 3   <0.0001 <0.0001 <0.0001 0.9839 1 > 2 ≈ 3  
 GGI <0.0001 <0.0001 0.0008 0.9303 1 > 2 ≈ 3   0.0004 0.0003 0.0031 0.9902 1 > 2 ≈ 3  
 RS <0.0001 <0.0001 <0.0001 0.0006 1 > 2 > 3   <0.0001 <0.0001 <0.0001 0.0183 1 > 2 > 3  
  1. 1: ≤ 40 years; 2: 40 < x < 70 years; 3: ≥ 70 years; ER oestrogen receptor, IFN interferon, IRGS iron regulatory gene signature, CIN chromosomal instability, MITO/OXPHOS mitochondrial oxidative phosphorylation, NS not significant (p > 0.05), 70-GES van’t Veer and colleagues prognostic GES, GGI genomic grade index, RS recurrence score