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Table 2 Exclusive upstream regulators in human necrotizing enterocolitis

From: Gene expression profiling in necrotizing enterocolitis reveals pathways common to those reported in Crohn’s disease

Upstream Regulator Molecule Type Predicted Activation State Activation z-score Target molecules in dataset
EBI3 Cytokine Activated 2.646 CD80, HLA-A, HLA-C, HLA-DMA, HLA-DMB, HLA-OB, HLA-DQA1
KDM5B Transcription regulator Activated 2.343 CAV1, GAL, GCA, MCAM, MT1H, MT1X, PTPLA, REEP1, TUBB2A
JAK1 Kinase Activated 2 HLA-A, HLA-C, IFIT2, MX1
TICAM1 Other Activated 2 CXCL10, IFIT1, IFIT2, IL8
SOCS3 Phosphatase Inhibited −2.433 CXCL10, IFIT1, IFIT2, IL6, MX1, OAS1, OAS2
SOCS1 Other Inhibited −2.586 CXCL10, IFIH1, IFIT1, IFIT2, MX1, OAS1, OAS2