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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses

Fig. 4

Coexpression networks underling HDM-driven CD4 T cell responses in sensitized asthmatics. a Heatmap illustrating the gene coexpression network. Increasing red intensity indicates increasing strength of correlation between genes. Modules are defined as the branch-like structures on the dendrogram. b Differentially expressed genes were identified between HDM-driven CD4 T cell responses in sensitized asthmatics versus nonsensitized controls and the –Log10 p-values were plotted on a module by module basis. c Molecular drivers of the blue modules were identified employing upstream regulator analysis. d The wiring diagram of the blue module was reconstructed employing prior knowledge from the Ingenuity Systems database

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