Fig. 4

Coexpression networks underling HDM-driven CD4 T cell responses in sensitized asthmatics. a Heatmap illustrating the gene coexpression network. Increasing red intensity indicates increasing strength of correlation between genes. Modules are defined as the branch-like structures on the dendrogram. b Differentially expressed genes were identified between HDM-driven CD4 T cell responses in sensitized asthmatics versus nonsensitized controls and the –Log10 p-values were plotted on a module by module basis. c Molecular drivers of the blue modules were identified employing upstream regulator analysis. d The wiring diagram of the blue module was reconstructed employing prior knowledge from the Ingenuity Systems database